Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 14/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.45 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19876288 | 0.78 | BTK (0.67) | BTKEPHX2NR1H4 | |
| SCHEMBL17646014 | 0.73 | EPHX2 (0.58) | BTKEPHX2NR1H4 | |
| SCHEMBL20358517 | 0.70 | BTK (0.45) | BTKEPHX2NR1H4 | |
| SCHEMBL20358519 | 0.70 | BTK (0.45) | BTKEPHX2NR1H4 | |
| SCHEMBL15678744 | 0.69 | EPHX2 (0.58) | BTKEPHX2NR1H4 | |
| SCHEMBL17660352 | 0.69 | EPHX2 (0.53) | BTKEPHX2NR1H4 | |
| SCHEMBL15678703 | 0.68 | BTK (0.56) | BTKEPHX2NR1H4 | |
| SCHEMBL15678747 | 0.68 | BTK (0.54) | BTKEPHX2NR1H4 | |
| SCHEMBL20359273 | 0.68 | BTK (0.45) | BTK | |
| SCHEMBL20360028 | 0.68 | BTK (0.44) | BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018035080-A1 | 2-OXO-IMIDAZOPYRIDINES AS REVERSIBLE BTK INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2018-02-22 | — | — | WO | disclosed |