Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MYC | P01106 | 1/20 | 0.49 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | AGER | Q15109 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 3/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1994315 | 0.84 | MYC (0.56) | MYCNAPRTL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL1988242 | 0.84 | MYC (0.49) | MYCNAPRTL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL1989020 | 0.84 | MAPK1 (0.53) | L3MBTL1KDM4EALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL1992956 | 0.77 | CAPN1 (0.50) | CAPN1 | |
| SCHEMBL9900917 | 0.74 | CAPN1 (0.57) | MYCNAPRTL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL541283 | 0.74 | CAPN1 (0.58) | MYCNAPRTL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL540979 | 0.74 | CAPN1 (0.58) | MYCCAPN1 | |
| SCHEMBL912675 | 0.71 | KDM4E (0.77) | MYCNAPRTL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL31586013 | 0.71 | KDM4E (0.77) | MYCNAPRTL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL1989132 | 0.70 | CAPN1 (0.59) | MYCNAPRTDHODHCAPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150252017-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS V | AbbVie Deutschland GmbH & Co. KG (DE) | 2015-09-10 | — | — | US | disclosed |
| US-9051304-B2 | Carboxamide compounds and their use as calpain inhibitors V | AbbVie Deutschland GmbH & Co. KG (DE) | 2015-06-09 | — | — | US | disclosed |
| EP-2516393-B1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS | ABBVIE DEUTSCHLAND (DE) | 2014-10-29 | — | — | EP | disclosed |
| US-20140179702-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS IV | AbbVie Deutschland GmbH & Co. KG (DE) | 2014-06-26 | — | — | US | disclosed |
| US-8598211-B2 | Carboxamide compounds and their use as calpain inhibitors IV | ABBVIE INC. (US) | 2013-12-03 | — | — | US | disclosed |
| EP-2516393-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS | Abbott GmbH & Co. KG (DE) | 2012-10-31 | — | — | EP | disclosed |
| EP-2516415-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS IV | Abbott GmbH & Co. KG (DE) | 2012-10-31 | — | — | EP | disclosed |
| WO-2011076812-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS IV | ABBOTT GMBH & CO. KG (DE) | 2011-06-30 | — | — | WO | disclosed |
| WO-2011076811-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS | ABBOTT GMBH & CO. KG (DE) | 2011-06-30 | — | — | WO | disclosed |
| US-20110152325-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS IV | ABBOTT GMBH & CO. KG (DE) | 2011-06-23 | — | — | US | disclosed |
| US-20110152265-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS V | ABBOTT GMBH & CO. KG (DE) | 2011-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150252017-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS V | CAPN2, CAPN1, CAPNS1 | MYC 1503/4885NAPRT 3604/4885L3MBTL1 4081/4885 |
| US-20140179702-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS IV | CAPN2, CAPNS1, CAPN1 | MYC 2611/4885NAPRT 1530/4885L3MBTL1 3392/4885 |
| US-20110152325-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS IV | CAPN2, CAPN1, CAPN9 | MYC 1967/4885NAPRT 3817/4885L3MBTL1 4035/4885 |
| US-20110152265-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS V | CAPN2, CAPN1, CAPNS1 | MYC 1503/4885NAPRT 3604/4885L3MBTL1 4081/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.