Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.38 |
| ▸ | ANPEP | P15144 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19899196 | 1.00 | SMN1; SMN2 (0.46) | SMN1; SMN2EPHX1CYP2C19TAAR1SLC6A2 | |
| SCHEMBL1287678 | 0.81 | EPHX1 (0.55) | EPHX1TAAR1SLC6A2SIGMAR1MAOA | |
| Aletamine SCHEMBL122065 | 0.77 | EPHX1 (0.64) | SMN1; SMN2EPHX1TAAR1SLC6A2SIGMAR1 | |
| SCHEMBL15184700 | 0.77 | TRPA1 (0.44) | SMN1; SMN2EPHX1CYP2C19TAAR1SLC6A2 | |
| SCHEMBL10901103 | 0.77 | SMN1; SMN2 (0.44) | SMN1; SMN2EPHX1CYP2C19TAAR1SLC6A2 | |
| SCHEMBL3257633 | 0.77 | SMN1; SMN2 (0.44) | SMN1; SMN2EPHX1CYP2C19TAAR1SLC6A2 | |
| SCHEMBL5159235 | 0.77 | EPHX1 (0.46) | SMN1; SMN2EPHX1CYP2C19TAAR1SLC6A2 | |
| SCHEMBL2369596 | 0.77 | TRPA1 (0.44) | SMN1; SMN2EPHX1CYP2C19TAAR1SLC6A2 | |
| SCHEMBL1071466 | 0.77 | TAAR1 (0.48) | SMN1; SMN2EPHX1TAAR1SLC6A2SIGMAR1 | |
| Aletamine SCHEMBL5038065 | 0.77 | EPHX1 (0.64) | SMN1; SMN2EPHX1TAAR1SLC6A2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10259779-B2 | Structural requirements of histone deacetylase inhibitors: C4-modified SAHA analogs display dual HDAC6/HDAC8 selectivity | WAYNE STATE UNIVERSITY (US) | 2019-04-16 | — | — | US | disclosed |
| US-20180057448-A1 | Structural requirements of histone deacetylase inhibitors: C4-modified saha analogs display dual HDAC6/HDAC8 selectivity | WAYNE STATE UNIVERSITY | 2018-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10259779-B2 | Structural requirements of histone deacetylase inhibitors: C4-modified SAHA analogs display dual HDAC6/HDAC8 selectivity | HDAC8, HDAC6, HDAC1 | SMN1; SMN2 3367/4885EPHX1 4499/4885CYP2C19 3099/4885 |
| US-20180057448-A1 | Structural requirements of histone deacetylase inhibitors: C4-modified saha analogs display dual HDAC6/HDAC8 selectivity | HDAC8, HDAC6, HDAC1 | SMN1; SMN2 3367/4885EPHX1 4499/4885CYP2C19 3099/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.