Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TACR3 | P29371 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1352644 | 0.87 | AKT1 (0.39) | LMNAKMT2AHTTSMN1; SMN2RAB9A | |
| SCHEMBL12803747 | 0.86 | KMT2A (0.47) | LMNATP53KMT2ATHRBRAB9A | |
| SCHEMBL1350490 | 0.85 | AKT1 (0.41) | LMNAKMT2AHTTSMN1; SMN2RAB9A | |
| SCHEMBL12597695 | 0.85 | NAMPT (0.49) | TP53KMT2A | |
| SCHEMBL12803268 | 0.84 | KLKB1 (0.49) | LMNATP53KMT2ATHRBRAB9A | |
| Hydrochloric Acid SCHEMBL1981812 | 0.83 | KLKB1 (0.48) | LMNATP53KMT2ATHRBRAB9A | |
| SCHEMBL12803421 | 0.83 | KLKB1 (0.48) | LMNATP53KMT2ARAB9ATACR3 | |
| SCHEMBL1352017 | 0.83 | MEN1 (0.37) | LMNAKMT2AHTTSMN1; SMN2 | |
| Methylamine SCHEMBL1981809 | 0.83 | CNR1 (0.52) | LMNATP53KMT2AHTTTHRB | |
| SCHEMBL1352166 | 0.82 | ADK (0.42) | KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075383-A1 | INHIBITORS OF AKT ACTIVITY | MERCK SHARP & DOHME CORP. (US) | 2011-06-23 | — | — | WO | disclosed |