Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 20/20 | 1.00 |
| ▸ | DAPK1 | P53355 | 3/20 | 1.00 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 1.00 |
| ▸ | BMP2K | Q9NSY1 | 3/20 | 1.00 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 1.00 |
| ▸ | MYLK2 | Q9H1R3 | 3/20 | 1.00 |
| ▸ | DAPK3 | O43293 | 2/20 | 1.00 |
| ▸ | JAK2 | O60674 | 2/20 | 1.00 |
| ▸ | HIPK4 | Q8NE63 | 2/20 | 1.00 |
| ▸ | CIT | O14578 | 2/20 | 1.00 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 1.00 |
| ▸ | PKN2 | Q16513 | 1/20 | 1.00 |
| ▸ | TLK2 | Q86UE8 | 1/20 | 1.00 |
| ▸ | STK39 | Q9UEW8 | 1/20 | 1.00 |
| ▸ | TLK1 | Q9UKI8 | 1/20 | 1.00 |
| ▸ | GAK | O14976 | 3/20 | 0.83 |
| ▸ | HTR2B | P41595 | 1/20 | 0.83 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.83 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.79 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30059552 | 1.00 | AAK1 (1.00) | AAK1DAPK1MKNK2BMP2KMKNK1 | |
| SCHEMBL17155348 | 1.00 | AAK1 (1.00) | AAK1DAPK1MKNK2BMP2KMKNK1 | |
| SCHEMBL17143243 | 0.93 | AAK1 (0.86) | AAK1DAPK1MKNK2BMP2KMKNK1 | |
| SCHEMBL30059578 | 0.91 | AAK1 (1.00) | AAK1DAPK1MKNK2BMP2KMKNK1 | |
| SCHEMBL30059562 | 0.91 | AAK1 (1.00) | AAK1DAPK1MKNK2BMP2KMKNK1 | |
| SCHEMBL17155572 | 0.91 | AAK1 (1.00) | AAK1DAPK1MKNK2BMP2KMKNK1 | |
| SCHEMBL19901194 | 0.91 | AAK1 (1.00) | AAK1DAPK1MKNK2BMP2KMKNK1 | |
| SCHEMBL17155610 | 0.91 | AAK1 (1.00) | AAK1DAPK1MKNK2BMP2KMKNK1 | |
| SCHEMBL20573929 | 0.88 | AAK1 (1.00) | AAK1DAPK1MKNK2BMP2KMKNK1 | |
| SCHEMBL21649248 | 0.88 | AAK1 (1.00) | AAK1DAPK1MKNK2BMP2KMKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250262197-A1 | COMPOUNDS AND METHODS FOR TREATING CHEMOTHERAPY-INDUCED PAIN | LEXICON PHARMACEUTICALS, INC. (US) | 2025-08-21 | — | — | US | disclosed |
| CN-115484951-A | AAK1 inhibitors for the treatment of viral infections | 莱西肯医药有限公司 | 2022-12-16 | — | — | CN | disclosed |
| US-10981910-B2 | Biaryl kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2021-04-20 | — | — | US | disclosed |
| CN-112142655-A | Biaryl kinase inhibitors | 百时美施贵宝公司 | 2020-12-29 | — | — | CN | disclosed |
| CN-108368084-B | Biaryl kinase inhibitors | 百时美施贵宝公司 | 2020-10-16 | — | — | CN | disclosed |
| US-20200317671-A1 | BIARYL KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2020-10-08 | — | — | US | disclosed |
| US-10544120-B2 | Biaryl kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2020-01-28 | — | — | US | disclosed |
| US-10544120-B2 | Biaryl kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2020-01-28 | — | — | US | disclosed |
| US-10351563-B2 | Biaryl kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-07-16 | — | — | US | disclosed |
| US-20190048006-A1 | BIARYL KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2019-02-14 | — | — | US | disclosed |
| US-20180346440-A1 | BIARYL KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2018-12-06 | — | — | US | disclosed |
| US-9902722-B2 | Biaryl kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-02-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10981910-B2 | Biaryl kinase inhibitors | AAK1, NCK1, MARCKS | AAK1 1/4885DAPK1 9/4885MKNK2 45/4885 |
| US-20200317671-A1 | BIARYL KINASE INHIBITORS | AAK1, NCK1, MARCKS | AAK1 1/4885DAPK1 9/4885MKNK2 45/4885 |
| US-20180346440-A1 | BIARYL KINASE INHIBITORS | AAK1, CAMKK1, CAMKK2 | AAK1 1/4885DAPK1 15/4885MKNK2 31/4885 |
| US-10544120-B2 | Biaryl kinase inhibitors | AAK1, CAMKK1, CAMKK2 | AAK1 1/4885DAPK1 15/4885MKNK2 31/4885 |
| US-20190048006-A1 | BIARYL KINASE INHIBITORS | AAK1, NCK1, MARCKS | AAK1 1/4885DAPK1 9/4885MKNK2 45/4885 |
| US-10351563-B2 | Biaryl kinase inhibitors | AAK1, NCK1, MARCKS | AAK1 1/4885DAPK1 9/4885MKNK2 45/4885 |
| US-20250262197-A1 | COMPOUNDS AND METHODS FOR TREATING CHEMOTHERAPY-INDUCED PAIN | PNCK, CAMKK1, CAMK2G | AAK1 33/4885DAPK1 53/4885MKNK2 144/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.