Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 6/20 | 0.49 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 6/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | NCF1 | P14598 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19901062 | 0.88 | NPC1 (0.51) | PTGDR2MCHR1MAPTKDM4ELMNA | |
| SCHEMBL19901542 | 0.77 | KMT2A (0.48) | PDE10AMCHR1MAPTKDM4EHTT | |
| SCHEMBL4309362 | 0.77 | MAPT (0.71) | MAPTKDM4EHTTLMNAPOLB | |
| SCHEMBL2850710 | 0.75 | MCHR1 (0.59) | PDE10AMCHR1MAPTKDM4ELMNA | |
| SCHEMBL19901063 | 0.71 | MCHR1 (0.41) | PDE10AMCHR1LMNA | |
| SCHEMBL12545620 | 0.70 | KMT2A (0.58) | KDM4EHTTLMNAPOLB | |
| SCHEMBL22672489 | 0.69 | PARP1 (0.45) | KDM4ELMNA | |
| SCHEMBL8871879 | 0.69 | PTGDR2 (0.64) | PTGDR2MAPTKDM4EHTTLMNA | |
| SCHEMBL23195553 | 0.68 | MAPT (0.46) | MAPTKDM4EPOLBNPSR1 | |
| SCHEMBL1614613 | 0.68 | KDM4E (0.72) | MAPTKDM4EHTTLMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9902710-B2 | Substituted 6, 7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (PDE 10A) | EXONHIT THERAPEUTICS, SA (FR) | 2018-02-27 | — | — | US | disclosed |