Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FER | P16591 | 12/20 | 0.78 |
| ▸ | SYK | P43405 | 7/20 | 0.78 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.62 |
| ▸ | JAK2 | O60674 | 2/20 | 0.62 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.62 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.62 |
| ▸ | HCK | P08631 | 2/20 | 0.62 |
| ▸ | ROS1 | P08922 | 2/20 | 0.62 |
| ▸ | PIM1 | P11309 | 2/20 | 0.62 |
| ▸ | PRKACA | P17612 | 2/20 | 0.62 |
| ▸ | MARK3 | P27448 | 2/20 | 0.62 |
| ▸ | LTK | P29376 | 2/20 | 0.62 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.62 |
| ▸ | CLK2 | P49760 | 2/20 | 0.62 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.62 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.62 |
| ▸ | MAP3K10 | Q02779 | 2/20 | 0.62 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.62 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.62 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10250587 | 0.90 | FER (0.82) | FERSYKMAPK1JAK2ROCK2 | |
| SCHEMBL2713216 | 0.88 | SYK (1.00) | FERSYKMAPK1JAK2ROCK2 | |
| SCHEMBL2713511 | 0.88 | SYK (1.00) | FERSYKMAPK1JAK2ROCK2 | |
| SCHEMBL19901817 | 0.81 | NPC1 (0.56) | FERSYKMAPK1KCNH2MAPK3 | |
| SCHEMBL9103569 | 0.80 | SYK (0.82) | FERSYKMAPK1JAK2ROCK2 | |
| SCHEMBL2716733 | 0.80 | SYK (0.82) | FERSYKMAPK1JAK2ROCK2 | |
| SCHEMBL6154806 | 0.80 | SYK (0.85) | FERSYKMAPK1JAK2ROCK2 | |
| SCHEMBL6154803 | 0.80 | SYK (0.85) | FERSYKMAPK1JAK2ROCK2 | |
| SCHEMBL5027051 | 0.79 | FER (0.71) | FERSYKMAPK1JAK2ROCK2 | |
| SCHEMBL6158559 | 0.77 | FER (1.00) | FERSYKMAPK1JAK2ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9902688-B2 | Benzamides and nicotinamides as Syk modulators | PORTOLA PHARMACEUTICALS, INC. (US) | 2018-02-27 | — | — | US | disclosed |