Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 7/20 | 0.39 |
| ▸ | GAA | P10253 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.38 |
| ▸ | MEN1 | O00255 | 5/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 6/20 | 0.34 |
| ▸ | RAB9A | P51151 | 5/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | NSD2 | O96028 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19902480 | 0.81 | LMNA (0.44) | LMNAMAPTGAAKMT2AMEN1 | |
| SCHEMBL3882060 | 0.70 | MAPT (0.66) | LMNAMAPTGAAKMT2AMEN1 | |
| SCHEMBL13790858 | 0.70 | MAPT (0.66) | LMNAMAPTGAAKMT2AMEN1 | |
| SCHEMBL3882063 | 0.70 | MAPT (0.66) | LMNAMAPTGAAKMT2AMEN1 | |
| SCHEMBL14572341 | 0.66 | LMNA (0.60) | LMNAMAPTGAAKMT2AMEN1 | |
| SCHEMBL14159217 | 0.66 | LMNA (0.60) | LMNAMAPTGAAKMT2AMEN1 | |
| SCHEMBL1262942 | 0.64 | MAPT (0.68) | LMNAMAPTGAAKMT2AMEN1 | |
| SCHEMBL14607771 | 0.64 | MAPT (0.68) | LMNAMAPTGAAKMT2AMEN1 | |
| SCHEMBL1262943 | 0.64 | MAPT (0.68) | LMNAMAPTGAAKMT2AMEN1 | |
| SCHEMBL4614687 | 0.61 | KMT2A (0.53) | MAPTGAAKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9902702-B2 | Spirocycloheptanes as inhibitors of rock | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-02-27 | — | — | US | disclosed |