Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 20/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17454433 | 0.88 | ROCK2 (0.43) | ROCK2 | |
| SCHEMBL17437994 | 0.88 | ROCK2 (0.42) | ROCK2 | |
| SCHEMBL17452643 | 0.85 | ROCK2 (0.41) | ROCK2 | |
| SCHEMBL19902551 | 0.85 | ROCK2 (0.39) | ROCK2 | |
| SCHEMBL21946609 | 0.82 | ROCK2 (0.36) | ROCK2 | |
| SCHEMBL19902682 | 0.80 | ROCK2 (0.52) | ROCK2 | |
| SCHEMBL21948588 | 0.78 | CNR2 (0.38) | ROCK2 | |
| SCHEMBL19151443 | 0.74 | ROCK2 (0.61) | ROCK2 | |
| SCHEMBL23889014 | 0.73 | ROCK2 (0.43) | ROCK2 | |
| SCHEMBL17454485 | 0.72 | KDM4E (0.41) | ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9902702-B2 | Spirocycloheptanes as inhibitors of rock | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-02-27 | — | — | US | disclosed |