Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 6/20 | 0.49 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.45 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 2/20 | 0.41 |
| ▸ | CNR2 | P34972 | 2/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
| ▸ | PLAT | P00750 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 2/20 | 0.36 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.32 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.32 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20229571 | 0.85 | CNR1 (0.46) | RIPK1PSMB8PSMB9CNR1CNR2 | |
| SCHEMBL17454466 | 0.81 | PSMB8 (0.45) | RIPK1PSMB8PSMB9CNR1CNR2 | |
| SCHEMBL10203516 | 0.81 | PSMB8 (0.45) | RIPK1PSMB8PSMB9CNR1CNR2 | |
| SCHEMBL22649247 | 0.80 | FAAH (0.47) | PSMB8PSMB9PLAT | |
| SCHEMBL2795047 | 0.80 | PSMB8 (0.44) | PSMB8PSMB9CNR1CNR2PDK1 | |
| SCHEMBL15273676 | 0.77 | PLAT (0.49) | PSMB8PSMB9CNR1CNR2PDK1 | |
| SCHEMBL17452575 | 0.77 | PSMB8 (0.48) | PSMB8PSMB9CNR1CNR2PDK1 | |
| SCHEMBL15567074 | 0.75 | PSMB8 (0.52) | PSMB8PSMB9CNR1CNR2PDK1 | |
| SCHEMBL11927683 | 0.75 | PSMB8 (0.49) | PSMB8PSMB9CNR1CNR2PDK1 | |
| SCHEMBL24013573 | 0.75 | PSMB8 (0.49) | PSMB8PSMB9PLAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9902702-B2 | Spirocycloheptanes as inhibitors of rock | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-02-27 | — | — | US | disclosed |