Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | KIT | P10721 | 1/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.44 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.42 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17454456 | 0.84 | FLT3 (0.47) | CSF1RRETPDGFRBKITPDGFRA | |
| SCHEMBL2922603 | 0.82 | GAA (0.53) | CYP1A2 | |
| SCHEMBL2425146 | 0.82 | CYP2C9 (0.50) | CSF1RRETPDGFRBKITPDGFRA | |
| SCHEMBL31290648 | 0.81 | PDGFRA (0.45) | CSF1RRETPDGFRBKITPDGFRA | |
| SCHEMBL20518829 | 0.80 | ELANE (0.44) | CSF1RRETPDGFRBKITPDGFRA | |
| SCHEMBL20518799 | 0.80 | ALDH1A1 (0.52) | CSF1RRETPDGFRBKITPDGFRA | |
| SCHEMBL17452632 | 0.80 | FLT3 (0.47) | CSF1RRETPDGFRBKITPDGFRA | |
| SCHEMBL12143505 | 0.78 | CSF1R (0.51) | CSF1RRETPDGFRBKITPDGFRA | |
| SCHEMBL20229600 | 0.78 | FLT3 (0.44) | CSF1RRETPDGFRBKITPDGFRA | |
| SCHEMBL20518794 | 0.77 | CSF1R (0.45) | CSF1RRETPDGFRBKITPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9902702-B2 | Spirocycloheptanes as inhibitors of rock | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-02-27 | — | — | US | disclosed |