Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 3/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | SIK1 | P57059 | 3/20 | 0.35 |
| ▸ | SIK2 | Q9H0K1 | 3/20 | 0.35 |
| ▸ | SIK3 | Q9Y2K2 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 6/20 | 0.34 |
| ▸ | KIT | P10721 | 2/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19902435 | 0.91 | ROCK1 (0.39) | ROCK1ROCK2PARP1SIK1SIK2 | |
| SCHEMBL19902427 | 0.87 | ROCK1 (0.38) | ROCK1ROCK2PARP1TSHRCSF1R | |
| SCHEMBL19902652 | 0.81 | CSF1R (0.43) | ROCK1ROCK2SIK1SIK2SIK3 | |
| SCHEMBL17452955 | 0.80 | ROCK2 (0.49) | ROCK1ROCK2CSF1RKIT | |
| SCHEMBL20229826 | 0.78 | CSF1R (0.40) | ROCK1ROCK2PARP1TSHRCSF1R | |
| SCHEMBL19902410 | 0.73 | ROCK1 (0.45) | ROCK1ROCK2CSF1R | |
| SCHEMBL19902598 | 0.73 | CSF1R (0.42) | ROCK1ROCK2SIK1SIK2SIK3 | |
| SCHEMBL17452905 | 0.72 | ROCK2 (0.51) | ROCK1ROCK2PARP1SIK1SIK2 | |
| SCHEMBL17452980 | 0.72 | ROCK2 (0.53) | ROCK1ROCK2CSF1RKIT | |
| SCHEMBL19902434 | 0.72 | CSF1R (0.42) | ROCK1ROCK2CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9902702-B2 | Spirocycloheptanes as inhibitors of rock | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-02-27 | — | — | US | disclosed |