Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | EPHB3 | P54753 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 3/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.40 |
| ▸ | WNT1 | P04628 | 2/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | NEK2 | P51955 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 2/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.39 |
| ▸ | MARK3 | P27448 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 2/20 | 0.38 |
| ▸ | JAK3 | P52333 | 2/20 | 0.38 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17454339 | 0.87 | BRD4 (0.53) | CREBBPBRD4EPHB3GSK3BDYRK1A | |
| SCHEMBL17438060 | 0.86 | PIM1 (0.47) | CREBBPBRD4EPHB3FLT3NEK2 | |
| SCHEMBL17452626 | 0.82 | CREBBP (0.43) | CREBBPBRD4EPHB3GSK3BDYRK1A | |
| SCHEMBL20229576 | 0.82 | USP30 (0.52) | BRD4MKNK1MKNK2USP30MARK3 | |
| SCHEMBL25416397 | 0.74 | FLT3 (0.40) | DYRK1AFLT3PIM1PIM2MKNK1 | |
| SCHEMBL27430475 | 0.74 | PDK2 (0.48) | CREBBPBRD4EPHB3ABL1TGFBR1 | |
| SCHEMBL3689503 | 0.74 | PIK3CD (0.47) | EPHB3 | |
| SCHEMBL19997216 | 0.74 | EPHB3 (0.56) | EPHB3 | |
| SCHEMBL19997277 | 0.72 | ROCK1 (0.50) | EPHB3ABL1 | |
| SCHEMBL21946562 | 0.72 | FLT3 (0.59) | FLT3NEK2ABL1USP30CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9902702-B2 | Spirocycloheptanes as inhibitors of rock | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-02-27 | — | — | US | disclosed |