Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 16/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 15/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 11/20 | 0.42 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.40 |
| ▸ | EPHB3 | P54753 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3690721 | 0.89 | PIK3CD (0.49) | PIK3CDPIK3CAPIK3CBPIK3R1 | |
| SCHEMBL3684977 | 0.84 | PIK3CD (0.47) | PIK3CDPIK3CAPIK3CBPIK3R1EPHB3 | |
| SCHEMBL20229602 | 0.81 | HAT1 (0.42) | EPHB3 | |
| SCHEMBL19997216 | 0.78 | EPHB3 (0.56) | EPHB3 | |
| SCHEMBL3687915 | 0.75 | PIK3CD (0.52) | PIK3CDPIK3CAPIK3CBPIK3R1 | |
| SCHEMBL3687917 | 0.75 | PIK3CD (0.52) | PIK3CDPIK3CAPIK3CBPIK3R1 | |
| SCHEMBL20229813 | 0.75 | NPC1 (0.58) | EPHB3 | |
| SCHEMBL19997277 | 0.74 | ROCK1 (0.50) | EPHB3 | |
| SCHEMBL19902676 | 0.74 | CREBBP (0.41) | EPHB3 | |
| SCHEMBL19997313 | 0.72 | ROCK1 (0.52) | EPHB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010074586-A1 | PYRAZOLO[1,5-A]PYRIDINE AND IMIDAZO[1,2-A]PYRIDINE DERIVATIVES AND THEIR USE IN CANCER THERAPY | PATHWAY THERAPEUTICS LIMITED (NZ) | 2010-07-01 | — | — | WO | disclosed |