Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.36 |
| ▸ | DRD3 | P35462 | 9/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | POLQ | O75417 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 6/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2011238 | 0.82 | KDM4E (0.46) | TNKSCREBBPBRD4KDM4E | |
| SCHEMBL22079488 | 0.82 | DRD3 (0.40) | TNKSCREBBPDRD3MTNR1AMTNR1B | |
| SCHEMBL22723833 | 0.81 | SYK (0.44) | TNKSSYKKDM4E | |
| SCHEMBL28910011 | 0.81 | KDM4E (0.44) | TNKSCREBBPDRD3BRD4KDM4E | |
| Potassium Ion SCHEMBL23858799 | 0.79 | TNKS (0.39) | TNKSCREBBPDRD3BRD4POLQ | |
| SCHEMBL543378 | 0.78 | NR4A2 (0.45) | TNKSBRD4POLQKDM4E | |
| SCHEMBL21353788 | 0.77 | TNKS (0.44) | TNKSDRD3SYKDRD2 | |
| SCHEMBL15808418 | 0.75 | GAA (0.38) | TNKSCREBBPBRD4SYKKDM4E | |
| SCHEMBL30969206 | 0.75 | KEAP1 (0.43) | KDM4E | |
| SCHEMBL21040577 | 0.72 | TNKS (0.41) | TNKSDRD3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3287454-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2018-02-28 | — | — | EP | disclosed |