Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TACR1 | P25103 | 4/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TACR3 | P29371 | 2/20 | 0.35 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | XPO1 | O14980 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5788966 | 0.76 | MAPT (0.55) | MAPTTACR1CES2ALDH1A1TACR3 | |
| SCHEMBL25460884 | 0.71 | MAPT (0.49) | MAPTTACR1CES2ALDH1A1TACR3 | |
| SCHEMBL4028192 | 0.68 | APP (0.53) | MAPTTACR1CES2ALDH1A1LMNA | |
| SCHEMBL4030734 | 0.68 | CES2 (0.47) | MAPTTACR1CES2ALDH1A1HDAC3 | |
| SCHEMBL4251643 | 0.67 | MAPT (0.44) | MAPTTACR1CES2ALDH1A1RAPGEF4 | |
| SCHEMBL1202442 | 0.67 | CES2 (0.50) | MAPTTACR1CES2ALDH1A1TACR3 | |
| Hydrochloric Acid SCHEMBL5756823 | 0.67 | APP (0.51) | MAPTTACR1CES2ALDH1A1LMNA | |
| SCHEMBL440959 | 0.66 | CES2 (0.58) | MAPTCES2ALDH1A1RAPGEF4XPO1 | |
| SCHEMBL7216715 | 0.66 | CES2 (0.48) | MAPTCES2RAPGEF4ARXPO1 | |
| SCHEMBL4564009 | 0.66 | CES2 (0.48) | MAPTCES2RAPGEF4ARXPO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3067349-B1 | CARBOXYMETHYL PIPERIDINE DERIVATIVE | KISSEI PHARMACEUTICAL (JP) | 2018-02-28 | — | — | EP | disclosed |