SCHEMBL19903680

SCHEMBL19903680

Cc1cc(-c2cc(-n3c4ccccc4c4cc(-c5cccc(C#N)c5)ccc43)c(C#N)cc2-n2c3ccccc3c3cc(-c4cccc(C#N)c4)ccc32)cc(C(F)(F)F)c1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAT2A P31153 1/20 0.38
AR P10275 1/20 0.38
SYK P43405 1/20 0.37
PTPN5 P54829 1/20 0.36
PDK2 Q15119 1/20 0.34
GRM5 P41594 2/20 0.33
PTGER4 P35408 1/20 0.33
ENPP1 P22413 1/20 0.33
TRPA1 O75762 1/20 0.33
ALDH1A3 P47895 1/20 0.33
GRIN1 Q05586 1/20 0.33
GRIN2B Q13224 1/20 0.33
PTGDR2 Q9Y5Y4 1/20 0.33
MEN1 O00255 1/20 0.32
ALDH1A1 P00352 1/20 0.32
CYP1A2 P05177 1/20 0.32
CYP3A4 P08684 1/20 0.32
MAPK1 P28482 1/20 0.32
CYP2C19 P33261 1/20 0.32
KMT2A Q03164 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21440727 0.95 MAT2A (0.38) MAT2AARSYKPTPN5PDK2
SCHEMBL19917929 0.95 AR (0.38) MAT2AARSYKPTPN5PDK2
SCHEMBL19912429 0.94 AR (0.44) MAT2AARPTPN5PDK2PTGER4
SCHEMBL22822143 0.94 PTPN5 (0.39) MAT2ASYKPTPN5PDK2ENPP1
SCHEMBL19917919 0.94 PTPN5 (0.39) MAT2ASYKPTPN5PDK2ENPP1
SCHEMBL19912419 0.93 AR (0.38) ARCYP1A2CYP2C19XDH
SCHEMBL19912445 0.93 AR (0.37) ARPTGER4XDH
SCHEMBL19903682 0.92 AR (0.39) MAT2AARSYKPTPN5PDK2
SCHEMBL19912440 0.92 AR (0.36) ARPTGER4XDH
SCHEMBL19912433 0.91 AR (0.38) ARPTPN5CYP1A2CYP2C19XDH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3287450-A1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN ORGANIC OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2018-02-28 EP disclosed