Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 6/20 | 0.48 |
| ▸ | CDKL5 | O76039 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | KMO | O15229 | 2/20 | 0.40 |
| ▸ | RARB | P10826 | 6/20 | 0.39 |
| ▸ | RARA | P10276 | 5/20 | 0.39 |
| ▸ | RARG | P13631 | 4/20 | 0.39 |
| ▸ | POLQ | O75417 | 1/20 | 0.39 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.38 |
| ▸ | EPRS1 | P07814 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1951819 | 0.75 | MET (0.67) | METCDKL5 | |
| SCHEMBL1951365 | 0.73 | MET (0.59) | METCDKL5 | |
| SCHEMBL13571906 | 0.73 | MET (0.44) | METCDKL5PIM1CSNK2A1PIM3 | |
| SCHEMBL1427684 | 0.72 | MET (0.84) | METCDKL5 | |
| SCHEMBL13572399 | 0.72 | MET (0.58) | METCDKL5 | |
| SCHEMBL19140260 | 0.72 | MET (0.67) | METCDKL5 | |
| SCHEMBL23559549 | 0.72 | RARB (0.44) | KDM4ESMN1; SMN2AXLKMORARB | |
| Hydrochloric Acid SCHEMBL2379468 | 0.72 | MET (0.82) | METCDKL5 | |
| SCHEMBL23559593 | 0.72 | KDM4E (0.48) | METKDM4EAXLRARBRARA | |
| SCHEMBL30039568 | 0.70 | RARB (0.48) | KDM4EAXLKMORARBRARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3287449-A2 | SALTS OF 2-FLUORO-N-METHYL-4-[7-(QUINOLIN-6-YL-METHYL)- IMIDAZO[1,2-B][1,2,4]TRIAZIN-2-YL]BENZAMIDE AND PROCESSES RELATED TO PREPARING THE SAME | Incyte Holdings Corporation (US) | 2018-02-28 | — | — | EP | disclosed |