Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | ATM | Q13315 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | MET | P08581 | 3/20 | 0.44 |
| ▸ | CHKA | P35790 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1427396 | 0.84 | DAO (0.53) | DAONPC1RAB9APOLBKCNH2 | |
| SCHEMBL29723055 | 0.84 | DAO (0.53) | DAONPC1RAB9APOLBKCNH2 | |
| SCHEMBL9277814 | 0.83 | NPC1 (0.52) | DAONPC1RAB9APOLBKCNH2 | |
| SCHEMBL5546704 | 0.81 | DAO (0.54) | DAONPC1RAB9APOLBKCNH2 | |
| SCHEMBL4819797 | 0.79 | PDGFRB (0.47) | RAB9AALDH1A1HDAC3MEN1KMT2A | |
| SCHEMBL5540682 | 0.79 | DAO (0.51) | DAONPC1RAB9APOLBKCNH2 | |
| SCHEMBL2384202 | 0.78 | DAO (0.51) | DAONPC1RAB9APOLBKCNH2 | |
| SCHEMBL25354572 | 0.78 | DAO (0.57) | DAONPC1RAB9APOLBKCNH2 | |
| SCHEMBL6961498 | 0.78 | DAO (0.57) | DAONPC1RAB9APOLBKCNH2 | |
| SCHEMBL2597877 | 0.78 | ALDH1A1 (0.59) | DAONPC1RAB9APOLBKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3287449-A2 | SALTS OF 2-FLUORO-N-METHYL-4-[7-(QUINOLIN-6-YL-METHYL)- IMIDAZO[1,2-B][1,2,4]TRIAZIN-2-YL]BENZAMIDE AND PROCESSES RELATED TO PREPARING THE SAME | Incyte Holdings Corporation (US) | 2018-02-28 | — | — | EP | disclosed |