Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 19/20 | 0.65 |
| ▸ | ESR2 | Q92731 | 10/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7623508 | 0.87 | ESR1 (0.67) | ESR1ESR2 | |
| SCHEMBL7623500 | 0.87 | ESR1 (0.67) | ESR1ESR2 | |
| SCHEMBL25079639 | 0.85 | ESR1 (0.81) | ESR1ESR2MEN1KMT2ATDP1 | |
| SCHEMBL8627690 | 0.83 | ESR1 (0.60) | ESR1ESR2MEN1KMT2ATDP1 | |
| SCHEMBL1665657 | 0.83 | ESR1 (0.86) | ESR1ESR2MEN1KMT2ATDP1 | |
| SCHEMBL7104864 | 0.80 | ESR1 (1.00) | ESR1ESR2MEN1KMT2ATDP1 | |
| SCHEMBL31683627 | 0.77 | ESR1 (0.81) | ESR1ESR2MEN1KMT2ATDP1 | |
| SCHEMBL8562371 | 0.77 | ESR1 (0.76) | ESR1ESR2MEN1KMT2ATDP1 | |
| SCHEMBL8631942 | 0.77 | ESR1 (0.81) | ESR1ESR2MEN1KMT2ATDP1 | |
| SCHEMBL8626952 | 0.77 | ESR1 (0.80) | ESR1ESR2MEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2958907-B1 | BENZOTHIOPHENE DERIVATIVES AND COMPOSITIONS THEREOF AS SELECTIVE ESTROGEN RECEPTOR DEGRADERS | NOVARTIS AG (CH) | 2018-02-28 | — | — | EP | disclosed |