Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.62 |
| ▸ | ABL1 | P00519 | 9/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19545229 | 0.90 | ABL1 (0.54) | TRPV1ABL1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL19226013 | 0.88 | TRPV1 (0.68) | TRPV1ABL1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL15391815 | 0.85 | TRPV1 (0.67) | TRPV1ABL1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL15391724 | 0.83 | TRPV1 (0.63) | TRPV1ABL1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL15388744 | 0.83 | ABL1 (0.64) | TRPV1ABL1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL15392218 | 0.82 | ABL1 (0.66) | TRPV1ABL1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL15392510 | 0.82 | TRPV1 (0.67) | TRPV1ABL1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL15393163 | 0.82 | ABL1 (0.65) | TRPV1ABL1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL29771403 | 0.82 | TRPV1 (0.67) | TRPV1ABL1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL16623348 | 0.81 | TRPV1 (0.76) | TRPV1ABL1MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2858988-B1 | BENZAMIDE DERIVATIVES FOR INHIBITING THE ACTIVITY OF ABL1, ABL2 AND BCR-ABL1 | NOVARTIS AG (CH) | 2018-02-28 | — | — | EP | disclosed |