Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UGCG | Q16739 | 11/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | CCR1 | P32246 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | CCR3 | P51677 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.37 |
| ▸ | ACACB | O00763 | 1/20 | 0.37 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19904316 | 1.00 | UGCG (0.43) | UGCGNOTUMCCR1HRH1CCR3 | |
| SCHEMBL19904478 | 0.99 | UGCG (0.43) | UGCGNOTUMCCR1HRH1CCR3 | |
| SCHEMBL19904680 | 0.98 | UGCG (0.42) | UGCGNOTUMCCR1HRH1CCR3 | |
| SCHEMBL19904697 | 0.97 | UGCG (0.41) | UGCGNOTUMCCR1HRH1CCR3 | |
| SCHEMBL19904504 | 0.97 | UGCG (0.41) | UGCGNOTUMCCR1HRH1CCR3 | |
| SCHEMBL19904655 | 0.96 | UGCG (0.42) | UGCGNOTUMCCR1HRH1CCR3 | |
| SCHEMBL19904554 | 0.94 | UTS2R (0.40) | UGCGNOTUMCCR1HRH1CCR3 | |
| SCHEMBL19904637 | 0.94 | UTS2R (0.40) | UGCGNOTUMCCR1HRH1CCR3 | |
| SCHEMBL19904581 | 0.94 | UGCG (0.40) | UGCGNOTUMCCR1HRH1CCR3 | |
| SCHEMBL19904704 | 0.94 | P2RX3 (0.40) | UGCGNOTUMCCR3HTR1AP2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3063141-B1 | N-(1-HYDROXY-3-(PYRROLIDINYL)PROPAN-2-YL)PYRROLIDINE-3-CARBOXAMIDE DERIVATIVES AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | BIOMARIN PHARM INC (US) | 2018-02-28 | — | — | EP | disclosed |