Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 11/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | FFAR4 | Q5NUL3 | 5/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19904572 | 0.91 | FFAR4 (0.47) | ACACBFFAR4NOTUM | |
| SCHEMBL19904392 | 0.91 | ACACB (0.47) | ACACBHTR1ANOTUM | |
| SCHEMBL19904626 | 0.88 | HTR1A (0.48) | HTR1ANOTUMCHRM4 | |
| SCHEMBL19904573 | 0.87 | HTR1A (0.40) | ACACBHTR1ANOTUMCHRM4 | |
| SCHEMBL19904565 | 0.87 | HTR1A (0.44) | HTR1ANOTUMCHRM4 | |
| SCHEMBL19904520 | 0.86 | UGCG (0.42) | ACACBFFAR4 | |
| SCHEMBL19904617 | 0.84 | UGCG (0.42) | ACACBFFAR4 | |
| SCHEMBL19904473 | 0.84 | UGCG (0.42) | ACACBFFAR4 | |
| SCHEMBL19904613 | 0.84 | ACACB (0.38) | ACACBHTR1A | |
| SCHEMBL18094818 | 0.83 | UGCG (0.51) | ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3063141-B1 | N-(1-HYDROXY-3-(PYRROLIDINYL)PROPAN-2-YL)PYRROLIDINE-3-CARBOXAMIDE DERIVATIVES AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | BIOMARIN PHARM INC (US) | 2018-02-28 | — | — | EP | disclosed |