Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.36 |
| ▸ | BCL9 | O00512 | 3/20 | 0.36 |
| ▸ | CTNNB1 | P35222 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19904651 | 0.90 | CCR1 (0.43) | CCR1NOTUMHTR1AMEN1ALDH1A1 | |
| SCHEMBL19904415 | 0.90 | CCR1 (0.43) | CCR1NOTUMHTR1AMEN1ALDH1A1 | |
| SCHEMBL19904428 | 0.89 | UGCG (0.43) | CCR1NOTUMHTR1AFFAR1 | |
| SCHEMBL19904316 | 0.89 | UGCG (0.43) | CCR1NOTUMHTR1AFFAR1 | |
| SCHEMBL19904697 | 0.89 | UGCG (0.41) | CCR1NOTUMHTR1AFFAR1 | |
| SCHEMBL19904478 | 0.89 | UGCG (0.43) | CCR1NOTUMHTR1AFFAR1 | |
| SCHEMBL19904504 | 0.89 | UGCG (0.41) | CCR1NOTUMHTR1AFFAR1 | |
| SCHEMBL19904566 | 0.88 | NOTUM (0.39) | CCR1NOTUMHTR1AFFAR1MAPT | |
| SCHEMBL19904680 | 0.88 | UGCG (0.42) | CCR1NOTUMHTR1AFFAR1 | |
| SCHEMBL19904554 | 0.87 | UTS2R (0.40) | CCR1NOTUMHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3063141-B1 | N-(1-HYDROXY-3-(PYRROLIDINYL)PROPAN-2-YL)PYRROLIDINE-3-CARBOXAMIDE DERIVATIVES AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | BIOMARIN PHARM INC (US) | 2018-02-28 | — | — | EP | disclosed |