Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT1 | Q99873 | 4/20 | 0.37 |
| ▸ | NOS1 | P29475 | 2/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | PRMT6 | Q96LA8 | 5/20 | 0.33 |
| ▸ | PRMT8 | Q9NR22 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.32 |
| ▸ | TACR1 | P25103 | 1/20 | 0.31 |
| ▸ | NOS3 | P29474 | 1/20 | 0.30 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.30 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19904807 | 0.90 | PRMT1 (0.38) | PRMT1NOS1NOS2PRMT6PRMT8 | |
| SCHEMBL19904816 | 0.87 | PRMT1 (0.37) | PRMT1NOS1NOS2PRMT6PRMT8 | |
| SCHEMBL16124062 | 0.86 | PRMT1 (0.38) | PRMT1NOS1NOS2PRMT6PRMT8 | |
| SCHEMBL16124060 | 0.85 | PRMT1 (0.36) | PRMT1PRMT6PRMT8 | |
| SCHEMBL19904830 | 0.84 | PRMT1 (0.42) | PRMT1NOS1NOS2PRMT6PRMT8 | |
| SCHEMBL16129003 | 0.83 | PRMT1 (0.37) | PRMT1PRMT6PRMT8PRMT3CARM1 | |
| SCHEMBL16129081 | 0.81 | PRMT1 (0.37) | PRMT1PRMT6PRMT8PRMT3CARM1 | |
| SCHEMBL19432338 | 0.80 | PRMT1 (0.37) | PRMT1PRMT6PRMT8PRMT3CARM1 | |
| SCHEMBL16204216 | 0.80 | PRMT6 (0.35) | PRMT1PRMT6PRMT8CARM1 | |
| SCHEMBL16129069 | 0.78 | PRMT1 (0.38) | PRMT1PRMT6PRMT8PRMT3CARM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970134-B1 | PYRAZOLE DERIVATIVES AS PRMT1 INHIBITORS AND USES THEREOF | EPIZYME INC (US) | 2018-02-28 | — | — | EP | disclosed |