Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 2/20 | 0.42 |
| ▸ | FAAH | O00519 | 12/20 | 0.37 |
| ▸ | ABL1 | P00519 | 3/20 | 0.33 |
| ▸ | BCR | P11274 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19905485 | 0.95 | PRKDC (0.42) | PRKDCFAAHABL1BCR | |
| SCHEMBL17874696 | 0.92 | PRKDC (0.48) | PRKDCFAAHABL1BCRCYP1A2 | |
| SCHEMBL19905199 | 0.92 | PRKDC (0.38) | PRKDCFAAHABL1BCRCYP1A2 | |
| SCHEMBL19905097 | 0.92 | PRKDC (0.38) | PRKDCFAAHCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL20373310 | 0.91 | PRKDC (0.42) | PRKDCFAAHABL1BCR | |
| SCHEMBL22838703 | 0.90 | PRKDC (0.37) | PRKDCFAAHABL1BCRCYP1A2 | |
| SCHEMBL19355151 | 0.89 | PRKDC (0.39) | PRKDCFAAH | |
| SCHEMBL19905389 | 0.89 | PRKDC (0.37) | PRKDCFAAHABL1BCRCYP1A2 | |
| SCHEMBL19905192 | 0.89 | PRKDC (0.39) | PRKDCFAAHABL1BCR | |
| SCHEMBL19905048 | 0.88 | PRKDC (0.39) | PRKDCFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3057959-B1 | DNA-PK INHIBITORS | VERTEX PHARMA (US) | 2018-02-28 | — | — | EP | disclosed |