Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 4/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1601642 | 0.78 | ALK (0.51) | ALKNTRK1RIPK1 | |
| SCHEMBL19908262 | 0.72 | ALK (0.54) | ALKNTRK1RIPK1ROCK2 | |
| SCHEMBL1601371 | 0.70 | ALK (0.43) | ALKNTRK1RIPK1ROCK2 | |
| SCHEMBL1601638 | 0.70 | ALK (0.64) | ALKNTRK1RIPK1 | |
| SCHEMBL3824477 | 0.68 | ALK (0.47) | ALKNTRK1ROCK2 | |
| SCHEMBL3975528 | 0.68 | ALK (0.60) | ALKNTRK1RIPK1 | |
| SCHEMBL1601026 | 0.64 | ALK (0.70) | ALKNTRK1 | |
| SCHEMBL1601014 | 0.64 | ALK (0.77) | ALK | |
| SCHEMBL1601012 | 0.64 | ALK (0.77) | ALK | |
| SCHEMBL3988497 | 0.64 | ALK (0.59) | ALKNTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091951-B1 | PYRIDO[2,3-B]PYRAZINE AND [1,8]-NAPHTHYRIDINE DERIVATIVES AS ALK AND C-MET INHIBITORS | CEPHALON INC (US) | 2018-02-28 | — | — | EP | disclosed |