Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 10/20 | 0.47 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.33 |
| ▸ | ABL1 | P00519 | 2/20 | 0.33 |
| ▸ | LCK | P06239 | 2/20 | 0.33 |
| ▸ | CSF1R | P07333 | 2/20 | 0.33 |
| ▸ | RET | P07949 | 2/20 | 0.33 |
| ▸ | MET | P08581 | 2/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.33 |
| ▸ | LTK | P29376 | 2/20 | 0.33 |
| ▸ | FLT3 | P36888 | 2/20 | 0.33 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.33 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.33 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.33 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.33 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1601371 | 0.83 | ALK (0.43) | ALKTNIKROCK2PLA2G7HTR6 | |
| SCHEMBL19908262 | 0.81 | ALK (0.54) | ALKROCK2NTRK1 | |
| SCHEMBL1601642 | 0.80 | ALK (0.51) | ALKMETNTRK1 | |
| SCHEMBL1601012 | 0.74 | ALK (0.77) | ALKMET | |
| SCHEMBL3836595 | 0.70 | ALK (0.65) | ALKTNIKJAK2PRKD3MAP4K4 | |
| SCHEMBL3592949 | 0.68 | ALK (0.68) | ALKTNIKJAK2PRKD3MAP4K4 | |
| SCHEMBL19908230 | 0.68 | ALK (0.39) | ALKROCK2NTRK1 | |
| SCHEMBL1601236 | 0.65 | ALK (0.69) | ALKJAK2PRKD3MAP4K4ABL1 | |
| SCHEMBL1600634 | 0.65 | ALK (0.67) | ALKTNIKJAK2PRKD3MAP4K4 | |
| SCHEMBL3592946 | 0.65 | ALK (0.66) | ALKTNIKJAK2PRKD3MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091951-A2 | PYRIDO[2,3-B]PYRAZINE AND[1,8]-NAPHTYRIDINE DERIVATIVES AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2009-08-26 | — | — | EP | disclosed |
| WO-2007130468-A2 | PYRIDO [2, 3-B] PYRAZINE AND [1, 8] -NAPHTHYRIDINE DERIVATIVES AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2007-11-15 | — | — | WO | disclosed |