Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 6/20 | 0.55 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | MET | P08581 | 2/20 | 0.43 |
| ▸ | L3MBTL3 | Q96JM7 | 7/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.43 |
| ▸ | MBTD1 | Q05BQ5 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.42 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | EIF4E | P06730 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1601304 | 0.86 | ALK (0.70) | ALKIKBKBMETL3MBTL3L3MBTL1 | |
| SCHEMBL1601160 | 0.84 | ALK (0.70) | ALKIKBKBMETL3MBTL3L3MBTL1 | |
| SCHEMBL1602274 | 0.77 | ALK (0.72) | ALKL3MBTL3L3MBTL1MBTD1TP53BP1 | |
| SCHEMBL19908241 | 0.76 | POLB (0.48) | ALKMKNK1MKNK2 | |
| SCHEMBL1601395 | 0.75 | ALK (0.57) | ALKL3MBTL3L3MBTL1MBTD1TP53BP1 | |
| SCHEMBL1601570 | 0.75 | ALK (0.82) | ALKIKBKBMETL3MBTL3L3MBTL1 | |
| SCHEMBL1601143 | 0.75 | ALK (0.73) | ALKMETL3MBTL3L3MBTL1MBTD1 | |
| SCHEMBL1600272 | 0.74 | ALK (0.72) | ALKIKBKBMETL3MBTL3L3MBTL1 | |
| SCHEMBL487790 | 0.74 | MET (0.68) | METL3MBTL3L3MBTL1MBTD1TP53BP1 | |
| SCHEMBL1602224 | 0.74 | ALK (0.65) | ALKIKBKBMETL3MBTL3L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091951-B1 | PYRIDO[2,3-B]PYRAZINE AND [1,8]-NAPHTHYRIDINE DERIVATIVES AS ALK AND C-MET INHIBITORS | CEPHALON INC (US) | 2018-02-28 | — | — | EP | disclosed |