Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | PTGER1 | P34995 | 3/20 | 0.48 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.46 |
| ▸ | NAMPT | P43490 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1601872 | 0.92 | ALDH1A1 (0.51) | KDM4EALDH1A1MAPTGLAGAA | |
| SCHEMBL1601988 | 0.85 | ALK (0.50) | KDM4EALDH1A1MAPTGFERPTGER1 | |
| SCHEMBL1601076 | 0.84 | ALK (0.49) | KDM4EALDH1A1MAPTGFERALK | |
| SCHEMBL12052509 | 0.83 | ALK (0.50) | KDM4EALDH1A1MAPTGLAGAA | |
| SCHEMBL1602279 | 0.83 | ALK (0.49) | KDM4EALDH1A1MAPTGLAGFER | |
| SCHEMBL1601221 | 0.81 | ALK (0.72) | KDM4EALDH1A1MAPTGLAGAA | |
| SCHEMBL1600388 | 0.80 | ALK (0.50) | MAPTALKLMNAHPGDTSHR | |
| SCHEMBL1601377 | 0.80 | ALK (0.53) | KDM4EALDH1A1MAPTGFERALK | |
| SCHEMBL1600433 | 0.80 | ALK (0.63) | KDM4EALDH1A1MAPTGLAGAA | |
| SCHEMBL1602183 | 0.80 | ALK (0.48) | KDM4EALDH1A1MAPTGFERALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091951-B1 | PYRIDO[2,3-B]PYRAZINE AND [1,8]-NAPHTHYRIDINE DERIVATIVES AS ALK AND C-MET INHIBITORS | CEPHALON INC (US) | 2018-02-28 | — | — | EP | disclosed |