Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 10/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | GLA | P06280 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 2/20 | 0.41 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.40 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1601377 | 0.92 | ALK (0.53) | ALKMAPTKDM4EALDH1A1TP53 | |
| SCHEMBL19908279 | 0.89 | MAPT (0.48) | ALKMAPTKDM4EALDH1A1GLA | |
| SCHEMBL12052509 | 0.89 | ALK (0.50) | ALKMAPTKDM4EALDH1A1GLA | |
| SCHEMBL1601988 | 0.87 | ALK (0.50) | ALKMAPTKDM4EALDH1A1TP53 | |
| SCHEMBL19908395 | 0.82 | ALK (0.62) | ALKMAPTKDM4EALDH1A1GLA | |
| SCHEMBL1602279 | 0.82 | ALK (0.49) | ALKMAPTKDM4EALDH1A1GLA | |
| SCHEMBL1602183 | 0.82 | ALK (0.48) | ALKMAPTKDM4EALDH1A1TP53 | |
| SCHEMBL1601076 | 0.81 | ALK (0.49) | ALKMAPTKDM4EALDH1A1TP53 | |
| SCHEMBL1600388 | 0.81 | ALK (0.50) | ALKMAPTSCN2ASCN10A | |
| SCHEMBL19908352 | 0.81 | ALK (0.47) | ALKMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091951-B1 | PYRIDO[2,3-B]PYRAZINE AND [1,8]-NAPHTHYRIDINE DERIVATIVES AS ALK AND C-MET INHIBITORS | CEPHALON INC (US) | 2018-02-28 | — | — | EP | disclosed |