Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 8/20 | 0.47 |
| ▸ | CXCR3 | P49682 | 5/20 | 0.40 |
| ▸ | NAMPT | P43490 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12052509 | 0.90 | ALK (0.50) | ALKCXCR3CHEK1AURKAJAK2 | |
| SCHEMBL1601988 | 0.90 | ALK (0.50) | ALKCXCR3NAMPTMAPT | |
| SCHEMBL1602279 | 0.90 | ALK (0.49) | ALKCXCR3NAMPTTSHRCHEK1 | |
| SCHEMBL1601654 | 0.89 | CA2 (0.48) | ALKNAMPT | |
| SCHEMBL1601377 | 0.89 | ALK (0.53) | ALKCXCR3NAMPTCHEK1AURKA | |
| SCHEMBL1602183 | 0.88 | ALK (0.48) | ALKCXCR3TSHRMAPT | |
| SCHEMBL1601076 | 0.87 | ALK (0.49) | ALKCXCR3NAMPTMAPT | |
| SCHEMBL1601872 | 0.87 | ALDH1A1 (0.51) | ALKNAMPTMAPT | |
| SCHEMBL1602413 | 0.86 | ALK (0.49) | ALKCHEK1AURKAJAK2PRKD3 | |
| SCHEMBL1600388 | 0.85 | ALK (0.50) | ALKTSHRMAPTEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091951-B1 | PYRIDO[2,3-B]PYRAZINE AND [1,8]-NAPHTHYRIDINE DERIVATIVES AS ALK AND C-MET INHIBITORS | CEPHALON INC (US) | 2018-02-28 | — | — | EP | disclosed |