Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CKS1B | P61024 | 2/20 | 0.43 |
| ▸ | SKP1 | P63208 | 2/20 | 0.43 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.37 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16075342 | 0.86 | CKS1B (0.46) | CKS1BSKP1SKP2ALDH1A1PIK3CA | |
| SCHEMBL16075345 | 0.86 | GPR119 (0.48) | CKS1BSKP1SKP2GPR119 | |
| SCHEMBL16075328 | 0.83 | BTK (0.50) | CKS1BSKP1SKP2ALDH1A1HTT | |
| SCHEMBL16075343 | 0.77 | BTK (0.50) | CKS1BSKP1SKP2ALDH1A1PIK3CA | |
| SCHEMBL16075324 | 0.76 | JAK2 (0.48) | CKS1BSKP1SKP2GPR119 | |
| SCHEMBL16075329 | 0.75 | CKS1B (0.52) | CKS1BSKP1SKP2ALDH1A1LMNA | |
| SCHEMBL16075325 | 0.75 | CKS1B (0.47) | CKS1BSKP1SKP2ALDH1A1PIK3CA | |
| SCHEMBL3100957 | 0.75 | KMT2A (0.64) | CKS1BSKP1SKP2ALDH1A1LMNA | |
| SCHEMBL4938026 | 0.74 | MAPT (0.64) | ALDH1A1LMNAMAPTHTTNPSR1 | |
| SCHEMBL16075341 | 0.74 | SCD (0.51) | CKS1BSKP1SKP2TBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970163-B1 | 5-THIAZOLECARBOXAMIDE DERVATIVES AND THEIR USE AS BTK INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2018-02-28 | — | — | EP | disclosed |