Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.41 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 12/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP8B1 | Q9UNU6 | 1/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16033973 | 0.78 | P2RX7 (0.55) | PARP1TNKS2PARP2MKNK1ADORA1 | |
| SCHEMBL16033934 | 0.76 | P2RX7 (0.57) | PARP1TNKS2PARP2MKNK1MAPT | |
| SCHEMBL16033728 | 0.76 | P2RX7 (0.57) | PARP1TNKS2PARP2MKNK1ADORA1 | |
| SCHEMBL16034797 | 0.76 | P2RX7 (0.59) | PARP1TNKS2PARP2MKNK1ADORA1 | |
| SCHEMBL31518819 | 0.75 | ADORA1 (0.46) | PARP1TNKS2PARP2MKNK1ADORA1 | |
| SCHEMBL9951760 | 0.75 | ESR2 (0.48) | PARP1TNKS2PARP2MKNK1ADORA1 | |
| SCHEMBL30603343 | 0.74 | ESR2 (0.47) | PARP1TNKS2PARP2MKNK1ADORA1 | |
| SCHEMBL29899537 | 0.74 | MKNK1 (0.46) | PARP1TNKS2PARP2MKNK1ADORA1 | |
| SCHEMBL1497077 | 0.74 | MKNK1 (0.48) | PARP1TNKS2PARP2MKNK1ADORA1 | |
| SCHEMBL19959250 | 0.74 | ADORA1 (0.49) | PARP1TNKS2PARP2MKNK1ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3112366-B1 | P2X7 MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-02-28 | — | — | EP | disclosed |