Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 5/20 | 1.00 |
| ▸ | SRC | P12931 | 3/20 | 1.00 |
| ▸ | AXL | P30530 | 2/20 | 0.92 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.64 |
| ▸ | MAPK13 | O15264 | 6/20 | 0.64 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.64 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.64 |
| ▸ | BRAF | P15056 | 6/20 | 0.63 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.63 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.63 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.63 |
| ▸ | RAF1 | P04049 | 2/20 | 0.63 |
| ▸ | PLK4 | O00444 | 1/20 | 0.63 |
| ▸ | ACOX3 | O15254 | 1/20 | 0.63 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.63 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.63 |
| ▸ | JAK2 | O60674 | 1/20 | 0.63 |
| ▸ | ERN1 | O75460 | 1/20 | 0.63 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.63 |
| ▸ | STK10 | O94804 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19911121 | 0.96 | ABL1 (1.00) | ABL1SRCAXLMAPK14MAPK13 | |
| SCHEMBL12093783 | 0.90 | ABL1 (0.85) | ABL1SRCAXLMAPK14MAPK13 | |
| SCHEMBL19911110 | 0.90 | ABL1 (1.00) | ABL1SRCAXLMAPK14MAPK13 | |
| SCHEMBL5055295 | 0.89 | ABL1 (0.83) | ABL1SRCAXLMAPK14MAPK13 | |
| SCHEMBL5059981 | 0.88 | ABL1 (0.82) | ABL1SRCAXLMAPK14MAPK13 | |
| SCHEMBL5056300 | 0.88 | ABL1 (0.81) | ABL1SRCAXLMAPK14MAPK13 | |
| SCHEMBL5055270 | 0.87 | ABL1 (0.80) | ABL1SRCAXLMAPK14MAPK13 | |
| SCHEMBL2083920 | 0.86 | ABL1 (0.80) | ABL1SRCAXLMAPK14MAPK13 | |
| SCHEMBL17122426 | 0.86 | ABL1 (0.79) | ABL1SRCAXLMAPK14MAPK13 | |
| SCHEMBL2083222 | 0.86 | ABL1 (0.79) | ABL1SRCAXLMAPK14MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10196378-B2 | Inhibitors of BCR-ABL mutants and use thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2019-02-05 | — | — | US | disclosed |
| WO-2018039467-A1 | INHIBITORS OF-BCR-ABL MUTANTS AND USE THEREOF | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2018-03-01 | — | — | WO | disclosed |
| US-20180057479-A1 | Inhibitors of BCR-ABL Mutants and Use Thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2018-03-01 | — | — | US | disclosed |
| US-20180057479-A1 | Inhibitors of BCR-ABL Mutants and Use Thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2018-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180057479-A1 | Inhibitors of BCR-ABL Mutants and Use Thereof | ABL1, BCR, ABL2 | ABL1 1/4885SRC 15/4885AXL 744/4885 |
| US-10196378-B2 | Inhibitors of BCR-ABL mutants and use thereof | ABL1, BCR, ABL2 | ABL1 1/4885SRC 15/4885AXL 744/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.