Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 4/20 | 0.79 |
| ▸ | AXL | P30530 | 1/20 | 0.79 |
| ▸ | SRC | P12931 | 3/20 | 0.75 |
| ▸ | MAPK14 | Q16539 | 11/20 | 0.68 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.68 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.68 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.68 |
| ▸ | DDR2 | Q16832 | 3/20 | 0.68 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.68 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.66 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.58 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | BRAF | P15056 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2083920 | 0.91 | ABL1 (0.80) | ABL1AXLSRCMAPK14MAPK13 | |
| SCHEMBL17122426 | 0.91 | ABL1 (0.79) | ABL1AXLSRCMAPK14MAPK13 | |
| SCHEMBL19911121 | 0.88 | ABL1 (1.00) | ABL1AXLSRCMAPK14MAPK13 | |
| SCHEMBL2080237 | 0.88 | MAPK14 (0.73) | ABL1AXLSRCMAPK14MAPK13 | |
| SCHEMBL17122413 | 0.87 | ABL1 (0.74) | ABL1AXLSRCMAPK14MAPK13 | |
| SCHEMBL19911115 | 0.86 | ABL1 (1.00) | ABL1AXLSRCMAPK14MAPK13 | |
| SCHEMBL2080246 | 0.84 | ABL1 (1.00) | ABL1AXLSRCMAPK14MAPK11 | |
| SCHEMBL2081895 | 0.83 | ABL1 (0.70) | ABL1AXLSRCMAPK14MAPK13 | |
| SCHEMBL12093783 | 0.82 | ABL1 (0.85) | ABL1AXLSRCMAPK14MAPK13 | |
| SCHEMBL19911110 | 0.82 | ABL1 (1.00) | ABL1AXLSRCMAPK14MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163756-B2 | For example,1-(3-t-butyl-1- (1,2,3,4-tetrahydro- isoquinolin-6-yl)-1H- pyrazol-5-yl)-3-(3- cyanophenyl)urea; for treatment of mammalian cancers and inflammatory diseases including rheumatoid arthritis, retinopathies | DECIPHERA PHARMACEUTICALS, LLC (US) | 2012-04-24 | — | — | US | disclosed |
| US-8163756-B2 | For example,1-(3-t-butyl-1- (1,2,3,4-tetrahydro- isoquinolin-6-yl)-1H- pyrazol-5-yl)-3-(3- cyanophenyl)urea; for treatment of mammalian cancers and inflammatory diseases including rheumatoid arthritis, retinopathies | DECIPHERA PHARMACEUTICALS, LLC (US) | 2012-04-24 | — | — | US | disclosed |
| US-20080113967-A1 | ENZYME MODULATORS AND TREATMENTS | DECIPHERA PHARMACEUTICALS, LLC (US) | 2008-05-15 | — | — | US | disclosed |
| US-20080113967-A1 | ENZYME MODULATORS AND TREATMENTS | DECIPHERA PHARMACEUTICALS, LLC (US) | 2008-05-15 | — | — | US | disclosed |
| EP-1835934-A2 | ENZYME MODULATORS AND TREATMENTS | Deciphera Pharmaceuticals, LLC (US) | 2007-09-26 | — | — | EP | disclosed |
| US-20070078121-A1 | Enzyme modulators and treatments | DECIPHERA PHARMACEUTICALS, LLC | 2007-04-05 | — | — | US | disclosed |
| US-20070078121-A1 | Enzyme modulators and treatments | DECIPHERA PHARMACEUTICALS, LLC | 2007-04-05 | — | — | US | disclosed |
| WO-2006071940-A2 | ENZYME MODULATORS AND TREATMENTS | DECIPHERA PHARMACEUTICALS, LLC (US) | 2006-07-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070078121-A1 | Enzyme modulators and treatments | ABL1, ABL2, LCK | ABL1 1/4885AXL 56/4885SRC 9/4885 |
| US-20080113967-A1 | ENZYME MODULATORS AND TREATMENTS | ABL2, BRAF, MAP3K1 | ABL1 20/4885AXL 117/4885SRC 69/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.