Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTRA1 | Q92743 | 20/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21104748 | 0.86 | HTRA1 (0.62) | HTRA1 | |
| SCHEMBL19912652 | 0.86 | HTRA1 (0.62) | HTRA1 | |
| SCHEMBL21099290 | 0.83 | HTRA1 (0.55) | HTRA1 | |
| SCHEMBL19914746 | 0.81 | HTRA1 (0.44) | HTRA1 | |
| SCHEMBL19899279 | 0.81 | HTRA1 (0.44) | HTRA1 | |
| SCHEMBL19912873 | 0.77 | HTRA1 (0.42) | HTRA1 | |
| SCHEMBL21059288 | 0.76 | HTRA1 (0.66) | HTRA1 | |
| SCHEMBL21059290 | 0.76 | HTRA1 (0.66) | HTRA1 | |
| SCHEMBL19899726 | 0.75 | HTRA1 (0.60) | HTRA1 | |
| SCHEMBL19899723 | 0.75 | HTRA1 (0.60) | HTRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018036957-A1 | NEW TRIFLUOROMETHYLPROPANAMIDE DERIVATIVES AS HTRA1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2018-03-01 | — | — | WO | disclosed |