SCHEMBL19913115

SCHEMBL19913115

Cc1cc(-c2ccc3c4ccc(-c5cc(C)cc(C(F)(F)F)c5)cc4n(-c4cc(-c5ccncc5)c(-n5c6cc(-c7cc(C)cc(C(F)(F)F)c7)ccc6c6ccc(-c7cc(C)cc(C(F)(F)F)c7)cc65)cc4C#N)c3c2)cc(C(F)(F)F)c1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP11B1 P15538 2/20 0.34
CYP11B2 P19099 2/20 0.34
XDH P47989 2/20 0.34
AR P10275 2/20 0.33
METAP2 P50579 1/20 0.33
KDM4E B2RXH2 1/20 0.33
PDE5A O76074 1/20 0.33
LMNA P02545 1/20 0.33
HPGD P15428 1/20 0.33
TSHR P16473 1/20 0.33
PTGS1 P23219 1/20 0.33
PDE4A P27815 1/20 0.33
CYP2C19 P33261 1/20 0.33
BLM P54132 1/20 0.33
PDE4B Q07343 1/20 0.33
PDE4C Q08493 1/20 0.33
PDE4D Q08499 1/20 0.33
PDE3B Q13370 1/20 0.33
PDE3A Q14432 1/20 0.33
KLRK1 P26718 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22019654 0.99 CYP11B1 (0.34) CYP11B1CYP11B2XDHARMETAP2
SCHEMBL19913127 0.96 AR (0.33) CYP11B1CYP11B2XDHARMETAP2
SCHEMBL19919461 0.93 CYP11B1 (0.37) CYP11B1CYP11B2XDHMETAP2SQOR
SCHEMBL19912450 0.92 AR (0.37) CYP11B1CYP11B2XDHARTSHR
SCHEMBL19913116 0.91 AR (0.33) CYP11B1CYP11B2XDHARMETAP2
SCHEMBL19913118 0.91 CYP11B1 (0.33) CYP11B1CYP11B2XDHARMETAP2
SCHEMBL19909014 0.90 PDE3B (0.38) CYP11B1CYP11B2XDHKDM4EPDE5A
SCHEMBL19919460 0.89 CYP11B1 (0.35) CYP11B1CYP11B2METAP2SQORSCN5A
SCHEMBL21440706 0.89 AR (0.36) CYP11B1CYP11B2XDHARTSHR
SCHEMBL19913252 0.89 METAP2 (0.34) CYP11B1CYP11B2XDHARMETAP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180062085-A1 ORGANIC MOLECULES FOR USE IN OPTOELECTRONIC DEVICES SAMSUNG DISPLAY CO., LTD. (KR) 2018-03-01 US disclosed