SCHEMBL19913294

SCHEMBL19913294

Cc1ccc(-c2ccc3c(c2)c2cc(-c4ccc(C(F)(F)F)cc4C)ccc2n3-c2cc(C#N)cc(-n3c4ccc(-c5ccc(C(F)(F)F)cc5C)cc4c4cc(-c5ccc(C(F)(F)F)cc5C)ccc43)c2-c2cc(-c3ccccc3)nc(-c3ccccc3)c2)c(C(F)(F)F)c1

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 6/20 0.34
HPGD P15428 4/20 0.34
ADORA2A P29274 2/20 0.34
ADORA1 P30542 2/20 0.34
PPARG P37231 1/20 0.34
NCOA2 Q15596 1/20 0.34
NCOA1 Q15788 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34
NCOA3 Q9Y6Q9 1/20 0.34
ALDH1A1 P00352 4/20 0.33
MAPT P10636 3/20 0.33
L3MBTL1 Q9Y468 3/20 0.33
TDP1 Q9NUW8 2/20 0.33
HCRTR1 O43613 2/20 0.33
HCRTR2 O43614 2/20 0.33
AR P10275 1/20 0.33
GAA P10253 1/20 0.33
TP53 P04637 1/20 0.33
RXFP1 Q9HBX9 1/20 0.33
POLB P06746 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19913295 0.95 KDM4E (0.33) KDM4EHPGDADORA2AADORA1PPARG
SCHEMBL19909444 0.92 ALOX5AP (0.36) KDM4EHPGDNPSR1ALDH1A1MAPT
SCHEMBL19919476 0.89 ALOX5AP (0.34) KDM4EHPGDNPSR1ALDH1A1MAPT
SCHEMBL19913319 0.89 KDM4E (0.38) KDM4EHPGDADORA2AADORA1PPARG
SCHEMBL19909415 0.88 KDM4E (0.41) KDM4EHPGDADORA2AADORA1PPARG
SCHEMBL19912511 0.86 AR (0.32) ARAKR1C3AKR1C2
SCHEMBL19909172 0.86 KDM4E (0.39) KDM4EHPGDADORA2AADORA1PPARG
SCHEMBL19913168 0.85 LRRK2 (0.32) HCRTR1HCRTR2ARCYP2C9SCN9A
SCHEMBL19913259 0.85 AR (0.37) KDM4EHPGDADORA2AADORA1PPARG
SCHEMBL22563580 0.85 ALOX5AP (0.36) KDM4EHPGDNPSR1ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180062085-A1 ORGANIC MOLECULES FOR USE IN OPTOELECTRONIC DEVICES SAMSUNG DISPLAY CO., LTD. (KR) 2018-03-01 US disclosed