Sugi Predict

Sugi Predict / Compounds / SCHEMBL19914577

SCHEMBL19914577

SCHEMBL19914577

CC(C)c1cc(NCCCN(C)C(=O)OC(C)(C)C)nc(NC(=O)Nc2ccc(OC(F)(F)F)cc2)n1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MCHR1 Q99705 7/20 0.43
▸ HTR2C P28335 2/20 0.43
▸ MCHR2 Q969V1 2/20 0.43
▸ EPHX2 P34913 2/20 0.40
▸ HDAC3 O15379 1/20 0.38
▸ HDAC4 P56524 1/20 0.38
▸ HDAC1 Q13547 1/20 0.38
▸ HDAC7 Q8WUI4 1/20 0.38
▸ HDAC2 Q92769 1/20 0.38
▸ HDAC10 Q969S8 1/20 0.38
▸ HDAC11 Q96DB2 1/20 0.38
▸ HDAC8 Q9BY41 1/20 0.38
▸ HDAC6 Q9UBN7 1/20 0.38
▸ HDAC9 Q9UKV0 1/20 0.38
▸ HDAC5 Q9UQL6 1/20 0.38
▸ ALDH1A1 P00352 2/20 0.37
▸ HPGD P15428 1/20 0.37
▸ P2RY1 P47900 2/20 0.36
▸ P2RY2 P41231 1/20 0.36
▸ P2RY14 Q15391 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19900224 0.91 MCHR1 (0.47) MCHR1HTR2CMCHR2EPHX2HDAC3
SCHEMBL19914615 0.90 MCHR1 (0.53) MCHR1HTR2CMCHR2EPHX2HDAC3
SCHEMBL23753662 0.88 EPHX1 (0.38) MCHR1HTR2CMCHR2ALDH1A1NPC1
SCHEMBL19914610 0.87 MCHR1 (0.42) MCHR1HTR2CMCHR2EPHX2HDAC3
SCHEMBL19914571 0.85 MAPK14 (0.38) MCHR1EPHX2ALDH1A1HPGDNPC1
SCHEMBL23258581 0.85 MCHR1 (0.45) MCHR1HTR2CMCHR2EPHX2HDAC3
SCHEMBL19900455 0.85 EPHX2 (0.46) MCHR1HTR2CMCHR2EPHX2HDAC3
SCHEMBL23761861 0.85 MCHR1 (0.34) MCHR1HTR2CMCHR2
SCHEMBL28861592 0.83 EPHX2 (0.48) MCHR1EPHX2HDAC3HDAC4HDAC1
SCHEMBL19900226 0.81 SCN9A (0.43) MCHR1HTR2CMCHR2EPHX2HDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12145913-B2 Inhibition of Olig2 activity Curtana Pharmaceuticals, Inc. (US) 2024-11-19 — — US disclosed
US-11242323-B2 Inhibition of OLIG2 activity Curtana Pharmaceuticals, Inc. (US) 2022-02-08 — — US disclosed
US-11242323-B2 Inhibition of OLIG2 activity Curtana Pharmaceuticals, Inc. (US) 2022-02-08 — — US disclosed
US-20210253535-A1 INHIBITION OF OLIG2 ACTIVITY Curtana Pharmaceuticals, Inc. 2021-08-19 — — US disclosed
US-20210253535-A1 INHIBITION OF OLIG2 ACTIVITY Curtana Pharmaceuticals, Inc. 2021-08-19 — — US disclosed
WO-2018039621-A1 INHIBITION OF OLIG2 ACTIVITY Curtana Pharmaceuticals, Inc. (US) 2018-03-01 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210253535-A1 INHIBITION OF OLIG2 ACTIVITY GLI2, ING2, GMFG MCHR1 4146/4885HTR2C 3524/4885MCHR2 3266/4885
US-12145913-B2 Inhibition of Olig2 activity POU2F2, POU2F1, PLP2 MCHR1 4605/4885HTR2C 2947/4885MCHR2 3461/4885
US-11242323-B2 Inhibition of OLIG2 activity POU2F2, ING2, PAX2 MCHR1 4230/4885HTR2C 3594/4885MCHR2 3069/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.