Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16884691 | 0.71 | TSHR (0.44) | TSHRTP53ALOX15 | |
| SCHEMBL19288031 | 0.67 | — | — | |
| SCHEMBL12677139 | 0.61 | — | — | |
| SCHEMBL2380934 | 0.61 | — | — | |
| SCHEMBL720412 | 0.61 | — | — | |
| Hydrogen Sulfide SCHEMBL15657642 | 0.59 | — | — | |
| SCHEMBL20865629 | 0.58 | ESR2 (0.33) | TSHRTP53 | |
| Carveol SCHEMBL180292 | 0.53 | TSHR (1.00) | TSHRTP53ALOX15 | |
| Carveol SCHEMBL20586300 | 0.53 | TSHR (1.00) | TSHRTP53ALOX15 | |
| Carveol SCHEMBL20201316 | 0.53 | TSHR (1.00) | TSHRTP53ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2268623-B9 | QUINAZOLINE DERIVATIVES AS RAF KINASE MODULATORS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORP (US) | 2018-02-28 | — | — | EP | disclosed |