Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.70 |
| ▸ | KDR | P35968 | 2/20 | 0.70 |
| ▸ | RET | P07949 | 1/20 | 0.70 |
| ▸ | KIF5B | P33176 | 1/20 | 0.70 |
| ▸ | LCK | P06239 | 1/20 | 0.70 |
| ▸ | BRAF | P15056 | 16/20 | 0.65 |
| ▸ | RAF1 | P04049 | 6/20 | 0.64 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.58 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.58 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.58 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17278106 | 0.89 | KDR (0.72) | EGFRKDRRETKIF5BLCK | |
| SCHEMBL16692917 | 0.86 | KDR (0.65) | EGFRKDRRETKIF5BLCK | |
| SCHEMBL1782126 | 0.84 | BRAF (0.72) | EGFRKDRRETKIF5BLCK | |
| SCHEMBL1012180 | 0.82 | KDR (0.73) | EGFRKDRRETKIF5BLCK | |
| SCHEMBL7209616 | 0.82 | KDR (1.00) | EGFRKDRRETKIF5BLCK | |
| SCHEMBL17053428 | 0.80 | BRAF (0.80) | EGFRLCKBRAFRAF1 | |
| SCHEMBL28010078 | 0.80 | BRAF (0.81) | BRAFRAF1 | |
| SCHEMBL17278109 | 0.79 | BRAF (0.67) | EGFRKDRRETKIF5BLCK | |
| SCHEMBL13680230 | 0.79 | BRAF (0.83) | EGFRKDRRETKIF5BBRAF | |
| SCHEMBL1013794 | 0.79 | BRAF (1.00) | BRAFRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2268623-B9 | QUINAZOLINE DERIVATIVES AS RAF KINASE MODULATORS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORP (US) | 2018-02-28 | — | — | EP | disclosed |