Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 1.00 |
| ▸ | RET | P07949 | 4/20 | 1.00 |
| ▸ | KIF5B | P33176 | 4/20 | 1.00 |
| ▸ | EGFR | P00533 | 2/20 | 0.73 |
| ▸ | LCK | P06239 | 1/20 | 0.73 |
| ▸ | BRAF | P15056 | 10/20 | 0.59 |
| ▸ | RAF1 | P04049 | 6/20 | 0.58 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.56 |
| ▸ | FLT1 | P17948 | 1/20 | 0.56 |
| ▸ | CDK2 | P24941 | 1/20 | 0.56 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.56 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.56 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.56 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.55 |
| ▸ | KDM1A | O60341 | 2/20 | 0.53 |
| ▸ | FLT3 | P36888 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1012180 | 0.85 | KDR (0.73) | KDRRETKIF5BEGFRLCK | |
| SCHEMBL17278106 | 0.84 | KDR (0.72) | KDRRETKIF5BEGFRLCK | |
| SCHEMBL19916680 | 0.82 | EGFR (0.70) | KDRRETKIF5BEGFRLCK | |
| SCHEMBL4375169 | 0.81 | KDM1A (0.76) | KDRRETKIF5BEGFRLCK | |
| SCHEMBL1782126 | 0.79 | BRAF (0.72) | KDRRETKIF5BEGFRLCK | |
| SCHEMBL1013313 | 0.79 | RET (0.65) | KDRRETKIF5BEGFRLCK | |
| SCHEMBL1013510 | 0.79 | RET (0.65) | KDRRETKIF5BEGFRLCK | |
| SCHEMBL16692917 | 0.79 | KDR (0.65) | KDRRETKIF5BEGFRLCK | |
| SCHEMBL15463598 | 0.79 | BRAF (0.69) | KDRRETKIF5BEGFRLCK | |
| SCHEMBL1013319 | 0.77 | KDM1A (0.67) | KDRRETKIF5BEGFRLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0880508-B1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | ASTRAZENECA AB (SE) | 2003-04-16 | — | — | EP | disclosed |
| US-6184225-B1 | ENDOTHELIAL GROWTH FACTOR INHIBITORS, ANGIOGENESIS INHIBITORS | ZENECA LIMITED (GB) | 2001-02-06 | — | — | US | disclosed |
| EP-0880508-A1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | ZENECA LIMITED (GB) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997030035-A1 | QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS | ZENECA LIMITED (GB) | 1997-08-21 | — | — | WO | disclosed |