Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALB | P02768 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | SHH | Q15465 | 1/20 | 0.47 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.47 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.47 |
| ▸ | SMO | Q99835 | 1/20 | 0.47 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19916728 | 0.92 | ALB (0.48) | ALBHTR1ASLC6A2PDE4AOPRM1 | |
| SCHEMBL19916704 | 0.83 | MAPT (0.70) | MAPTLMNAGAAHTT | |
| SCHEMBL15424158 | 0.81 | MAPT (0.49) | ALBHTR1ASLC6A2PDE4AOPRM1 | |
| SCHEMBL19685469 | 0.81 | ALB (0.48) | ALBHTR1ASLC6A2PDE4AOPRM1 | |
| SCHEMBL19132578 | 0.81 | NR1H4 (0.60) | ALBHTR1ASLC6A2PDE4AOPRM1 | |
| SCHEMBL15424150 | 0.79 | ALB (0.58) | ALBHTR1ASLC6A2PDE4AOPRM1 | |
| SCHEMBL2619398 | 0.76 | ALB (0.58) | ALBHTR1ASLC6A2PDE4AOPRM1 | |
| SCHEMBL15424139 | 0.76 | ALB (0.59) | ALBHTR1ASLC6A2PDE4AOPRM1 | |
| SCHEMBL28386672 | 0.76 | ALB (0.64) | ALBHTR1ASLC6A2PDE4AOPRM1 | |
| SCHEMBL19132583 | 0.75 | USP28 (0.59) | ALBHTR1ASLC6A2PDE4AOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2661425-B1 | HEDGEHOG ANTAGONISTS HAVING ZINC BINDING MOIETIES | CURIS INC (US) | 2018-02-28 | — | — | EP | disclosed |