Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.44 |
| ▸ | CCR2 | P41597 | 6/20 | 0.42 |
| ▸ | TACR1 | P25103 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.42 |
| ▸ | CASR | P41180 | 1/20 | 0.41 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.40 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.40 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PTGES | O14684 | 1/20 | 0.37 |
| ▸ | KCNB1 | Q14721 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19917727 | 1.00 | TRPA1 (0.44) | TRPA1CCR2TACR1OPRM1OPRL1 | |
| SCHEMBL19917654 | 0.91 | TRPA1 (0.46) | TRPA1CCR2TACR1OPRM1OPRL1 | |
| SCHEMBL19917758 | 0.91 | TRPA1 (0.46) | TRPA1CCR2TACR1OPRM1OPRL1 | |
| SCHEMBL19917769 | 0.87 | TRPA1 (0.42) | TRPA1CCR2TACR1OPRM1OPRL1 | |
| SCHEMBL19917772 | 0.85 | CASR (0.41) | TRPA1CCR2TACR1OPRM1OPRL1 | |
| SCHEMBL16894239 | 0.83 | TRPA1 (0.49) | TRPA1CCR2TACR1OPRM1OPRL1 | |
| SCHEMBL16894168 | 0.83 | TRPA1 (0.49) | TRPA1CCR2TACR1OPRM1OPRL1 | |
| SCHEMBL16894165 | 0.83 | TRPA1 (0.49) | TRPA1CCR2TACR1OPRM1OPRL1 | |
| SCHEMBL19917726 | 0.82 | TRPA1 (0.43) | TRPA1CCR2TACR1OPRM1OPRL1 | |
| SCHEMBL19917747 | 0.82 | TRPA1 (0.43) | TRPA1CCR2TACR1OPRM1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900642-B1 | SUBSTITUTED SULFONAMIDE COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2018-02-28 | — | — | EP | disclosed |