Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR3 | O14843 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.39 |
| ▸ | GRM3 | Q14832 | 2/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MTOR | P42345 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | GRM8 | O00222 | 1/20 | 0.39 |
| ▸ | GRM6 | O15303 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.39 |
| ▸ | PLCB1 | Q9NQ66 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28243791 | 0.84 | SMN1; SMN2 (0.41) | FFAR3SMN1; SMN2GRM2GRM3GRM4 | |
| SCHEMBL431288 | 0.82 | FFAR3 (0.59) | FFAR3SMN1; SMN2GRM2GRM3GRM4 | |
| SCHEMBL11799188 | 0.82 | FFAR3 (0.59) | FFAR3SMN1; SMN2GRM2GRM3GRM4 | |
| SCHEMBL16892280 | 0.80 | FFAR3 (0.56) | FFAR3SMN1; SMN2GRM2GRM3GRM4 | |
| SCHEMBL3470932 | 0.80 | FFAR3 (0.56) | FFAR3SMN1; SMN2GRM2GRM3GRM4 | |
| SCHEMBL23458958 | 0.79 | FFAR3 (0.62) | FFAR3SMN1; SMN2GRM2GRM3GRM4 | |
| SCHEMBL2232346 | 0.79 | SMN1; SMN2 (0.43) | SMN1; SMN2GRM2GRM3GRM4CYP2C19 | |
| SCHEMBL21834030 | 0.78 | FFAR3 (0.54) | FFAR3SMN1; SMN2GRM2GRM3GRM4 | |
| SCHEMBL21834034 | 0.78 | FFAR3 (0.54) | FFAR3SMN1; SMN2GRM2GRM3GRM4 | |
| SCHEMBL20855519 | 0.78 | SMN1; SMN2 (0.40) | FFAR3SMN1; SMN2TDP1GAANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180057505-A1 | BICYCLIC HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF THE PAR-2 SIGNALING PATHWAY | VERTEX PHARMACEUTICALS INCORPORATED | 2018-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180057505-A1 | BICYCLIC HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF THE PAR-2 SIGNALING PATHWAY | F2RL1, PARP12, TFPI2 | FFAR3 1249/4885SMN1; SMN2 4014/4885GRM2 2381/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.