Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 20/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14987160 | 0.91 | GLS (1.00) | GLS | |
| SCHEMBL22031147 | 0.84 | GLS (0.86) | GLS | |
| SCHEMBL20034338 | 0.83 | GLS (1.00) | GLS | |
| SCHEMBL15043789 | 0.81 | GLS (1.00) | GLS | |
| SCHEMBL22623513 | 0.77 | GLS (0.81) | GLS | |
| SCHEMBL19919947 | 0.77 | GLS (0.81) | GLS | |
| SCHEMBL19920147 | 0.76 | GLS (0.82) | GLS | |
| SCHEMBL22623478 | 0.75 | GLS (0.65) | GLS | |
| SCHEMBL14987195 | 0.73 | GLS (1.00) | GLS | |
| SCHEMBL2640644 | 0.72 | GLS (1.00) | GLS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2782570-B1 | HETEROCYCLIC INHIBITORS OF GLUTAMINASE | CALITHERA BIOSCIENCES INC (US) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018039442-A1 | TREATMENT OF CANCER WITH INHIBITORS OF GLUTAMINASE | CALITHERA BIOSCIENCES, INC. (US) | 2018-03-01 | — | — | WO | disclosed |