Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 20/20 | 0.78 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.72 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.72 |
| ▸ | JAK2 | O60674 | 1/20 | 0.64 |
| ▸ | TTK | P33981 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18194346 | 0.92 | LRRK2 (0.72) | LRRK2MAP3K9MKNK2JAK2TTK | |
| SCHEMBL29429993 | 0.87 | LRRK2 (1.00) | LRRK2MAP3K9MKNK2JAK2TTK | |
| SCHEMBL18018784 | 0.87 | LRRK2 (1.00) | LRRK2MAP3K9MKNK2JAK2TTK | |
| SCHEMBL19921131 | 0.84 | LRRK2 (0.60) | LRRK2MAP3K9MKNK2TTK | |
| SCHEMBL29432560 | 0.84 | LRRK2 (1.00) | LRRK2MAP3K9MKNK2JAK2 | |
| SCHEMBL29567607 | 0.84 | LRRK2 (1.00) | LRRK2MAP3K9MKNK2JAK2 | |
| SCHEMBL7454021 | 0.84 | LRRK2 (1.00) | LRRK2MAP3K9MKNK2JAK2 | |
| SCHEMBL17980606 | 0.83 | LRRK2 (0.77) | LRRK2MAP3K9MKNK2JAK2TTK | |
| SCHEMBL19921212 | 0.83 | LRRK2 (0.67) | LRRK2MAP3K9MKNK2TTK | |
| SCHEMBL18018881 | 0.82 | LRRK2 (1.00) | LRRK2MAP3K9MKNK2JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3290420-B1 | PYRIMIDINE PYRROLE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND USES THEREOF | UNIV XIAMEN (CN) | 2020-12-09 | — | — | EP | claimed |
| US-20180312508-A1 | PYRIMIDOPYRROLE COMPOUNDS, METHOD FOR PREPARING THE SAME, PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME AND USES THEREOF | XIAMEN UNIVERSITY (CN) | 2018-11-01 | — | — | US | claimed |
| EP-3290420-A1 | PYRIMIDINE PYRROLE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND USES THEREOF | Xiamen University (CN) | 2018-03-07 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180312508-A1 | PYRIMIDOPYRROLE COMPOUNDS, METHOD FOR PREPARING THE SAME, PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME AND USES THEREOF | TPMT, DHPS, TYMP | LRRK2 2861/4885MAP3K9 3080/4885MKNK2 4292/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.