Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 3/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | PDE5A | O76074 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | METAP2 | P50579 | 1/20 | 0.30 |
| ▸ | ADCY10 | Q96PN6 | 1/20 | 0.30 |
| ▸ | ALPL | P05186 | 1/20 | 0.30 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
| ▸ | HTR2B | P41595 | 1/20 | 0.30 |
| ▸ | GUCY1A1 | Q02108 | 1/20 | 0.30 |
| ▸ | GUCY1B1 | Q02153 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19922755 | 0.88 | ALDH1A1 (0.37) | ARALDH1A1KDM4ESMN1; SMN2TP53 | |
| SCHEMBL19922827 | 0.88 | TP53 (0.36) | ARALDH1A1KDM4ESMN1; SMN2TP53 | |
| SCHEMBL19922666 | 0.87 | AR (0.34) | ARALDH1A1KDM4ESMN1; SMN2TP53 | |
| Zagociguat SCHEMBL19922804 | 0.86 | AR (0.34) | ARALDH1A1KDM4ESMN1; SMN2TP53 | |
| SCHEMBL19922971 | 0.86 | AR (0.34) | ARALDH1A1KDM4ESMN1; SMN2TP53 | |
| Zagociguat SCHEMBL21333483 | 0.85 | PDE5A (0.35) | ARALDH1A1KDM4ESMN1; SMN2TP53 | |
| Zagociguat SCHEMBL21332996 | 0.85 | AR (0.34) | ARALDH1A1KDM4ESMN1; SMN2TP53 | |
| SCHEMBL23510171 | 0.84 | AR (0.33) | ARALDH1A1KDM4ESMN1; SMN2TP53 | |
| SCHEMBL19922775 | 0.84 | AR (0.33) | ARALDH1A1KDM4ESMN1; SMN2TP53 | |
| Zagociguat SCHEMBL21332766 | 0.84 | PDE5A (0.34) | ARALDH1A1KDM4EPDE5APDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250326761-A1 | sGC STIMULATORS | TISENTO THERAPEUTICS INC (US) | 2025-10-23 | — | — | US | disclosed |
| US-20230372335-A1 | TREATMENT OF COGNITIVE IMPAIRMENT WITH A CNS-PENETRANT sGC STIMULATOR | CYCLERION THERAPEUTICS, INC. (US) | 2023-11-23 | — | — | US | disclosed |
| US-11731977-B2 | SGC stimulators | CYCLERION THERAPEUTICS, INC. (US) | 2023-08-22 | — | — | US | disclosed |
| US-11731977-B2 | SGC stimulators | CYCLERION THERAPEUTICS, INC. (US) | 2023-08-22 | — | — | US | disclosed |
| US-11731977-B2 | SGC stimulators | CYCLERION THERAPEUTICS, INC. (US) | 2023-08-22 | — | — | US | disclosed |
| EP-3872080-B1 | FUSED BICYCLIC SGC STIMULATORS | CYCLERION THERAPEUTICS INC (US) | 2023-08-16 | — | — | EP | disclosed |
| EP-3872080-B1 | FUSED BICYCLIC SGC STIMULATORS | CYCLERION THERAPEUTICS INC (US) | 2023-08-16 | — | — | EP | disclosed |
| US-20230130739-A1 | DEUTERATED sGC STIMULATORS | TISENTO THERAPEUTICS INC. | 2023-04-27 | — | — | US | disclosed |
| US-20220009937-A1 | sGC STIMULATORS | TISENTO THERAPEUTICS INC. | 2022-01-13 | — | — | US | disclosed |
| US-20220009937-A1 | sGC STIMULATORS | TISENTO THERAPEUTICS INC. | 2022-01-13 | — | — | US | disclosed |
| US-10472363-B2 | SGC stimulators | CYCLERION THERAPEUTICS, INC. (US) | 2019-11-12 | — | — | US | disclosed |
| US-10472363-B2 | SGC stimulators | CYCLERION THERAPEUTICS, INC. (US) | 2019-11-12 | — | — | US | disclosed |
| US-20190248794-A1 | sGC STIMULATORS | TISENTO THERAPEUTICS INC. | 2019-08-15 | — | — | US | disclosed |
| US-20190248794-A1 | sGC STIMULATORS | TISENTO THERAPEUTICS INC. | 2019-08-15 | — | — | US | disclosed |
| EP-3507291-A1 | FUSED BICYCLIC SGC STIMULATORS | Cyclerion Therapeutics, Inc. (US) | 2019-07-10 | — | — | EP | disclosed |
| WO-2018045276-A1 | FUSED BICYCLIC SGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2018-03-08 | — | — | WO | disclosed |
| WO-2018045276-A1 | FUSED BICYCLIC SGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2018-03-08 | — | — | WO | disclosed |
| US-20180065971-A1 | sGC STIMULATORS | TISENTO THERAPEUTICS INC. | 2018-03-08 | — | — | US | disclosed |
| US-20180065971-A1 | sGC STIMULATORS | TISENTO THERAPEUTICS INC. | 2018-03-08 | — | — | US | disclosed |
| US-20180065971-A1 | sGC STIMULATORS | TISENTO THERAPEUTICS INC. | 2018-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10472363-B2 | SGC stimulators | GUCY1A2, PRKG1, GMPS | AR 4543/4885ALDH1A1 2650/4885KDM4E 3250/4885 |
| US-20250326761-A1 | sGC STIMULATORS | GUCY1A2, PRKG1, GMPS | AR 4543/4885ALDH1A1 2650/4885KDM4E 3250/4885 |
| US-20230130739-A1 | DEUTERATED sGC STIMULATORS | PDE2A, GUCY1A2, PDE3A | AR 3370/4885ALDH1A1 4468/4885KDM4E 1672/4885 |
| US-20230372335-A1 | TREATMENT OF COGNITIVE IMPAIRMENT WITH A CNS-PENETRANT sGC STIMULATOR | GUCY1A2, GUCY1A1, GUCY1B2 | AR 4814/4885ALDH1A1 3312/4885KDM4E 2382/4885 |
| US-20180065971-A1 | sGC STIMULATORS | GUCY1A2, PRKG1, GMPS | AR 4543/4885ALDH1A1 2650/4885KDM4E 3250/4885 |
| US-20220009937-A1 | sGC STIMULATORS | GUCY1A2, PRKG1, GMPS | AR 4543/4885ALDH1A1 2650/4885KDM4E 3250/4885 |
| US-11731977-B2 | SGC stimulators | GUCY1A2, PRKG1, GMPS | AR 4543/4885ALDH1A1 2650/4885KDM4E 3250/4885 |
| US-20190248794-A1 | sGC STIMULATORS | GUCY1A2, PRKG1, GMPS | AR 4543/4885ALDH1A1 2650/4885KDM4E 3250/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.