Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 7/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 5/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.35 |
| ▸ | PAK4 | O96013 | 3/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19924213 | 1.00 | PDE4A (0.39) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL19924228 | 0.88 | TLR8 (0.47) | PDE4APDE4BPDE4CPDE4DTLR8 | |
| SCHEMBL19924231 | 0.88 | TLR8 (0.47) | PDE4APDE4BPDE4CPDE4DTLR8 | |
| SCHEMBL19935595 | 0.81 | TLR8 (0.54) | TLR8ALDH1A1TLR7 | |
| SCHEMBL19935525 | 0.78 | KCNH2 (0.56) | ADORA1TLR8TLR7 | |
| SCHEMBL19924286 | 0.77 | KCNH2 (0.41) | TLR8ALDH1A1TLR7 | |
| SCHEMBL19924288 | 0.77 | KCNH2 (0.41) | TLR8ALDH1A1TLR7 | |
| SCHEMBL30076081 | 0.77 | KCNH2 (0.41) | TLR8ALDH1A1TLR7 | |
| SCHEMBL19924245 | 0.76 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL19924243 | 0.76 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4DPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12522570-B2 | Toll like receptor modulator compounds | GILEAD SCIENCES, INC. (US) | 2026-01-13 | — | — | US | disclosed |
| US-20240254091-A1 | TOLL LIKE RECEPTOR MODULATOR COMPOUNDS | GILEAD SCIENCES, INC. | 2024-08-01 | — | — | US | disclosed |
| US-11827609-B2 | Toll like receptor modulator compounds | GILEAD SCIENCES, INC. (US) | 2023-11-28 | — | — | US | disclosed |
| US-11827609-B2 | Toll like receptor modulator compounds | GILEAD SCIENCES, INC. (US) | 2023-11-28 | — | — | US | disclosed |
| EP-3507276-B1 | TOLL LIKE RECEPTOR MODULATOR COMPOUNDS | GILEAD SCIENCES INC (US) | 2021-11-03 | — | — | EP | disclosed |
| EP-3507276-B1 | TOLL LIKE RECEPTOR MODULATOR COMPOUNDS | GILEAD SCIENCES INC (US) | 2021-11-03 | — | — | EP | disclosed |
| US-11124487-B2 | Toll like receptor modulator compounds | GILEAD SCIENCES, INC. (US) | 2021-09-21 | — | — | US | disclosed |
| US-11124487-B2 | Toll like receptor modulator compounds | GILEAD SCIENCES, INC. (US) | 2021-09-21 | — | — | US | disclosed |
| US-10370342-B2 | Toll like receptor modulator compounds | GILEAD SCIENCES, INC. (US) | 2019-08-06 | — | — | US | disclosed |
| US-10370342-B2 | Toll like receptor modulator compounds | GILEAD SCIENCES, INC. (US) | 2019-08-06 | — | — | US | disclosed |
| WO-2018045144-A1 | TOLL LIKE RECEPTOR MODULATOR COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2018-03-08 | — | — | WO | disclosed |
| US-20180065938-A1 | TOLL LIKE RECEPTOR MODULATOR COMPOUNDS | GILEAD SCIENCES, INC. | 2018-03-08 | — | — | US | disclosed |
| US-20180065938-A1 | TOLL LIKE RECEPTOR MODULATOR COMPOUNDS | GILEAD SCIENCES, INC. | 2018-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10370342-B2 | Toll like receptor modulator compounds | TLR8, TLR3, TLR6 | PDE4A 510/4885PDE4B 774/4885PDE4C 873/4885 |
| US-11124487-B2 | Toll like receptor modulator compounds | TLR8, TLR3, TLR6 | PDE4A 510/4885PDE4B 774/4885PDE4C 873/4885 |
| US-20240254091-A1 | TOLL LIKE RECEPTOR MODULATOR COMPOUNDS | TLR8, TLR3, TLR6 | PDE4A 510/4885PDE4B 774/4885PDE4C 873/4885 |
| US-20180065938-A1 | TOLL LIKE RECEPTOR MODULATOR COMPOUNDS | TLR8, TLR3, TLR6 | PDE4A 510/4885PDE4B 774/4885PDE4C 873/4885 |
| US-11827609-B2 | Toll like receptor modulator compounds | TLR8, TLR3, TLR6 | PDE4A 510/4885PDE4B 774/4885PDE4C 873/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.